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. 2018 Oct 29;8(19):5469–5481. doi: 10.7150/thno.28295

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Dopaminergic neurons-specific drug delivery analysis. (A) Cell uptake of B6ME-NPs and B6E-NPs in SH-SY5Y cells observed by CLSM. Nuclei: DAPI, blue; NPs: Cy5, red; lysosome: LysoTracker, green. Scale bar: 50 μm. (B) Quantitation of (A). (C) Cellular uptake of B6ME-NPs, B6E-NPs and MA in SH-SY5Y cells (2 h incubation) observed via flow cytometry. (D) Ultrathin sections of SH-SY5Y cells incubated with B6ME-NPs and B6E-NPs for 8 h were observed via TEM. Scale bar: 2 μm. (E) Quantitation of (D). Error bars indicate mean ± SD (n= 3). *P < 0.05, **P < 0.01, ***P < 0.001; (Tg + PBS), (Tg + B6ME-NPs) vs. WT. ^#P < 0.05, ^##P < 0.01, ^###P < 0.001; (Tg + EGCG) vs. (Tg + B6ME-NPs).