Public prescription drug plan coverage for antiretrovirals and the potential cost to people living with HIV in Canada: a descriptive study

Abstract

Background:

Antiretrovirals are expensive and people living with HIV may experience a range of financial burdens when accessing these medications. Our aim was to describe the policy of all Canadian public drug insurance programs for antiretroviral drugs and illustrated how these policies might affect patients’ annual out-of-pocket expenditures.

Methods:

In December 2017, we reviewed public drug programs offering antiretroviral coverage in Canada using government websites to summarize eligibility criteria. We estimated the annual out-of-pocket costs incurred by people living with HIV by applying the cost-sharing rules to 2 hypothetical cases, a single man and a married woman with a net household income of $39 000 and $80 000, respectively, receiving identical prescriptions in different jurisdictions.

Results:

We observed substantial variation in the subsidy provided based mainly on geography, income and age. All 5 federal programs and 6 of 13 provincial and territorial jurisdictions offered universal coverage. In the remaining regions, patients spend up to several thousand dollars annually depending on income (Manitoba), age and income (Ontario, Saskatchewan) and age, income and drug costs (Quebec and Newfoundland and Labrador). We found the greatest variation for our higher income case, with out-of-pocket expenses ranging from 0 to over 50% of the antiretroviral cost.

Interpretation:

There is considerable inter- and intra-jurisdiction heterogeneity in the cost-sharing policies for antiretrovirals across Canada’s public drug programs. Policy reforms that either eliminate or set national standards for copayments, deductibles or premiums would minimize variation and could reduce the risk of cost-associated non-adherence to HIV therapy.

International guidelines recommend that combination antiretroviral therapy for people living with human immunodeficiency virus (HIV) infection be initiated promptly after diagnosis and continued for life to decrease morbidity, mortality and the risk of transmission to uninfected people.^1–5 However, in Canada, the list price for firstline single-tablet regimens is approximately $15 000 per year,⁶ and none of Canada’s publicly funded drug plans provide universal coverage of all prescription drugs. In the absence of a single national plan, each of Canada’s 10 provinces and 3 territorial governments manages and delivers health care services for its residents, including medication coverage (several federal plans insure specific populations). Each plan decides on the eligibility criteria for public drug insurance and the level of subsidy and selects the products to be listed on its drug formulary. Consequently, Canadians with identical prescriptions may pay substantially different amounts and may rely on private insurance, public funders, out-of-pocket payments or a combination of these to pay for their medication.^7–9

Financial burdens are associated with medication nonadherence. ¹⁰ Research indicates that medicine costs sometimes compete with other demands, leading to cost-related nonadherence: patients may forego prescribed medications in favour of spending their resources on other priorities or they may alter a medication’s dosing to make a prescription last longer.^10,11 Accordingly, it may be important to address cost-sharing mechanisms that require large out-of-pocket payments for antiretrovirals, particularly for people without drug insurance and those with more limited income.^12,13 Nonadherence to antiretroviral therapy can lead to uncontrolled HIV replication and subsequently to increased risks of disease progression,¹⁴ drug resistance¹⁵ and HIV transmission.^16,17 Because viral suppression prevents infection at the individual level^5,16–18 and may be effective in reducing transmission at the population level,^19–21 consideration should be given to providing affordable and accessible antiretroviral therapy for all; this has been highlighted as a fundamental component of a public response to the HIV epidemic.² Our primary objective was to describe and compare the reimbursement policy of all Canadian public drug insurance programs for antiretroviral drugs. To illustrate the financial burden that people living with HIV in Canada encounter in trying to obtain their HIV medication, we used 2 clinical scenarios to estimate the potential annual out-of-pocket expenditures when patients are prescribed HIV medication in each jurisdiction.

Methods

Sources of data

We searched the government websites of all jurisdictions in Canada that offered coverage for antiretroviral drugs in December 2017 (Appendix 1, available at www.cmajopen.ca/content/6/4/E551/suppl/DC1). We extracted data including eligibility criteria, cost-sharing rules, permission to coordinate with private payers, and whether there were restrictions pertaining to the prescriber or the dispensing pharmacy (Appendix 2, available at www.cmajopen.ca/content/6/4/E551/suppl/DC1). To validate the data, we asked a pharmacist in each jurisdiction who had expertise in providing HIV care or who was familiar with that jurisdiction’s antiretroviral reimbursement plans and the systems required to secure drug coverage for individual patients to review the information for accuracy (with the exception of the federal programs and Nunavut, where we did not have an email address of a representative pharmacist). If there were incorrect data, the pharmacist consulted another local representative and a consensus was reached. We focused exclusively on HIV treatment; we did not assess coverage of antiretrovirals for HIV prevention.

Patient scenarios

To illustrate and compare the annual out-of-pocket expenditures for antiretrovirals in working people, we created 2 clinical scenarios that reflected typical patients seen in clinical practice who did not have any workplace or private drug insurance and did not belong to groups typically eligible for publicly funded drug coverage, such as seniors (age ≥ 65 yr), children and recipients of social assistance. The first case was a single man, aged 30 years, with no dependents and a net annual household income of $39 000. The second case was a married woman, aged 48 years, with 2 children and a net annual household income of $80 000. In each case, the person was prescribed abacavir/lamivudine/dolutegravir, a commonly prescribed first-line single-tablet antiretroviral regimen listed in all public drug formularies in Canada.

Calculation of costs

For each jurisdiction, we calculated each person’s expected annual expenditure for the antiretroviral regimen according to the applicable plan and the cost-sharing rules (Appendix 3, available at www.cmajopen.ca/content/6/4/E551/suppl/DC1). For example, in Nova Scotia, for both case scenarios, there is no premium and no deductible, but there are 4 copayments of $11.25 for each 90-day prescription totalling $45 annually. While there is also no premium in Ontario, the man with an income of $39 000 would be required to pay an annual deductible of $1344 (3.4% of $39 000) plus 4 copayments of $2 for each of his prescriptions, resulting in $1352 paid out-of-pocket. Each calculation was verified by the same pharmacist who confirmed coverage details and any discrepancies were resolved by consensus with a second local representative. We assumed a 90-day supply was obtained 4 times a year and, to simplify comparisons, we used the same income in each region, although programs use different income values to calculate benefits. For example, deductibles in Ontario are calculated using net household income, while Manitoba calculates a “total adjusted family income” as the total taxable income minus $3000 for each dependent under the age of 18 years. We calculated prescription costs using the amount reimbursed by Ontario’s Ministry of Health and Long-Term Care to pharmacies, as listed on the Ontario Drug Benefit Formulary in December 2017.⁶ We therefore assumed that prices were similar across jurisdictions and that any effects of negotiated price discounts were minimal and excluded mark-ups and professional fees. This was a descriptive, nonqualitative analysis without predetermined hypotheses; thus, no statistical analyses were conducted.

Ethics approval

Because this study did not involve human subjects, ethics approval was not required.

Results

Public prescription plans

We found inter- and intra-jurisdictional variability in cost-sharing rules for antiretrovirals across public drug programs (Table 1, Table 2). Five federal drug insurance programs and at least 1 program in each province or territory provided some form of financial assistance for registered residents of Canada requiring HIV treatment. All 5 federal programs, which are portable across the country, fully subsidized the cost of antiretrovirals for eligible patients regardless of their age or income. Beyond these programs, the governments of British Columbia, Alberta, Northwest Territories, Nunavut, and Prince Edward Island also offered universal coverage of antiretrovirals for all of their residents living with HIV. In New Brunswick, because premiums and co-payments were waived and not collected, the plan functioned as a universal one.

Table 1:

Characteristics of all publicly funded federal drug plans in Canada that cover antiretrovirals for adults and seniors, December 2017

Public drug program; eligibility	Cost-sharing requirements				Restrictions
	Premium*	Deductible†	Copayment‡	Coordinates with other payers	Prescriber	Pharmacy	Plan covers drugs not related to HIV
Non-Insured Health Benefits Program Registered First Nations persons, Inuit recognized by an Inuit land claim organization	$0	$0	$0	Private first	None	None	Yes
Interim Federal Health Program Resettled refugees, protected persons, refugee claimants, victims of human trafficking, detainees	$0	$0	$0	NA	Follows provincial policy	Follows provincial policy	Follows provincial formulary
Veteran Affairs Canada Prescription Drug Program Royal Canadian Mounted Police members, Canadian war veterans, eligible Canadian Armed Forces members, certain wartime civilians	$0	$0	$0	Private first	None	None	Benefits related to plan
Correctional Service Canada Federal inmates	$0	$0	$0	NA	CSC institution physician	CSC institution	Yes
Canadian Forces Health Services Canadian Armed Forces personnel, authorized visiting military forces, foreign military exchange personnel and their dependents	$0	$0	$0	NA	None	Local base pharmacy or community pharmacy if after hours	Yes

Note: CSC = Correctional Service Canada, NA = not applicable.

^*The amount an individual must pay to be enrolled in the program.

^†The amount that must be paid by the individual before the program pays for any part of the drug costs.

^‡The amount or portion an individual pays with each prescription filled.

Table 2:

Characteristics of all publicly funded provincial/territorial drug plans in Canada that cover antiretrovirals for adults and seniors, December 2017

Public drug program	Eligibility	Cost-sharing plan				Restrictions		Plan covers drugs not related to HIV
		Premium*	Deductible†	Copayment‡	Coordinates with other payers	Prescriber	Pharmacy
Alberta
Alberta Health Care Insurance Plan, Specialized High Cost Drug Program	Registered§ Alberta residents	$0	$0	$0	No	Yes	Yes	No
British Columbia
British Columbia Centre for Excellence HIV Drug Treatment Program	HIV-positive BC residents Residents with coverage from another jurisdiction awaiting BC medical coverage	$0	$0	$0	No	Yes¶	Yes	No
Manitoba
Pharmacare	Program Registered Manitoba residents	$0	3.05%–6.9% of adjusted family income**; not prorated; minimum $100/yr	$0	Province first	No	No	Yes
Employment and Income Assistance Program — Prescription Drugs		$0	$0	$0	Province first	No	No	Yes
New Brunswick
Prescription Drug Program, HIV/AIDS Plan	Registered New Brunswick residents not receiving private insurance	$0††	$0	$0††	No	Yes	Yes	No
Newfoundland and Labrador
Newfoundland and Labrador Prescription Drug Program (for registered residents of Newfoundland and Labrador)
Foundation Plan	Residents who qualify for income support benefits	$0	$0	$0	NA	No	No	Yes
Access Plan	Families with children with net income ≤ $42 870 Couples without children with net income ≤ $30 009 Single individuals with net income ≤ $27 151	$0	$0	20%–70% of total prescription cost (varies with income)	Private first	No	No	Yes
Assurance Plan	Residents with eligible drug costs that exceed 5% of net income < $40 000	$0	$0	Copayment rate = income × 5%/total drug expenditure	Private first	No	No	Yes
	Residents with eligible drug costs that exceed 7.5% of net income between $40 000 and $74 999	$0	$0	Copayment rate = income × 7.5%/total drug expenditure	Private first	No	No	Yes
	Residents with eligible drug costs that exceed 10% of net income $75 000 to < $149 999	$0	$0	Copayment rate = income × 10%/total drug expenditure	Private first	No	No	Yes
65Plus Plan	Residents ≥ age 65 yr who receive old age security benefits and guaranteed income supplement	$0	$0	Maximum $6 dispensing fee	Private first	No	No	Yes
Northwest Territories (NWT)
Extended Health Benefits for Specified Disease Conditions	Non-Indigenous registered NWT residents	$0	$0	$0	Private first	No	No	Yes
Métis Health Benefits Program	For registered Indigenous Métis who are residents of NWT	$0	$0	$0	Private first	No	No	Yes
Extended Health Benefits for Seniors Program	For non-Indigenous and non-Métis registered residents of NWT who are age ≥ 60 yr	$0	$0	$0	Private first	No	No	Yes
Nova Scotia
Nova Scotia Department of Health and Wellness — Provincial High Cost Drug Program	Registered residents of Nova Scotia	$0	$0	$11.25 dispensing fee	Private first	Yes	Yes	No
Nunavut
Extended Health Benefits Program	Non-Indigenous registered Nunavut residents with a specified condition Non-Indigenous residents age ≥ 65 yr Registered residents who are not fully covered by third-party insurance	$0	$0	$0	Private first	No	No	Yes
Ontario
Ontario Drug Benefit program	Residents of long-term care facilities Ontario residents enrolled in the Home Care Program People enrolled in Ontario Works for income support People enrolled in the Ontario Disability Support Program for income support and other services	$0	$0	$2 per prescription	Private first	Yes	No	Yes
	Registered residents age ≥ 65 yr with net annual income ≤ $19 300 (single) or net annual income ≤ $32 300 (with spouse)	$0	$0	$2 per prescription	Province first	Yes	No	Yes
	Registered residents age ≥ 65 yr with annual net income > $19 300 (single) or > $32 300 (with spouse)	$0	$100	$6.11 per prescription	Province first	Yes	No	Yes
	Registered Ontario residents enrolled in the Trillium Drug Program who have high drug costs relative to their income	$0	~4% of net household income; prorated and payable quarterly	$2 per prescription	Private first	Yes	No	Yes
Prince Edward Island (PEI)
PEI Pharmacare, AIDS/HIV Program	Registered HIV-positive residents of Prince Edward Island	$0	$0	$0	No	No	Yes	No
Quebec
Régie de l’assurance maladie du Québec
Régie de l’assurance maladie du Québec	Recipients of Social Assistance and Social Solidarity Program Single adults, age 18–25 yr, living with parents and full-time students in an educational institution at the secondary, college or university level	$0	$0	$0	No	No	No	Yes
	Registered Quebec residents age ≥ 65 yr receiving 94%–100% of the guaranteed income supplement, without private insurance	$0	$0	$0	No	No	No	Yes
	Registered Quebec residents age ≥ 65 yr receiving 1%–93% of the guaranteed income supplement, without private insurance	$0–$667 (varies with net family income)	$19.45 monthly	After deductible, (total cost of Rx – 19.45) × 34.8% up to maximum of $52.65/mo ($632/yr)	No	No	No	Yes
	Registered Quebec residents age ≥ 65 yr not receiving any guaranteed income supplement, without private insurance	$0–$667 (varies with net family income)	$19.45 monthly	After deductible, (total cost of Rx – 19.45) × 34.8% up to maximum of $88.83/mo ($1066/yr)	No	No	No	Yes
	Registered residents of Quebec without private insurance	$0–$667 (varies with net family income)	$19.45 monthly	After deductible, (total cost of Rx – 19.45) × 34.5% up to maximum of $88.83/mo ($1066/yr)	No	No	No	Yes
Saskatchewan‡‡
Saskatchewan Drug Plan
Special Support Plan	Registered residents with drug costs greater than 3.4% of taxable income	$0	3.4% of taxable income	$0	Province first	Yes	No	Yes
Seniors’ Drug Plan	Age ≥ 65 yr with net income of ≤ $68 000	$0	$0	Maximum of $25 per prescription	Province first	Yes	No	Yes
Supplementary Health Program		$0	$0	$2 per prescription	Province first	Yes	No	Yes
Yukon
Chronic Disease and Disability Benefits Program	Registered Yukon residents	$0	First $250 of eligible costs per year ($500 per family)	$0	Private first	Yes	No	Yes
Pharmacare and Extended Health Benefits Program	Registered residents age ≥ 65 yr, or > 60 yr and married to a Yukon resident who is ≥ 65 yr	$0	$0	$0	Private first	Yes	No	Yes

Note: NA = not applicable, Rx = prescription.

^*The amount an individual must pay to be enrolled in the program.

^†The amount that must be paid by the individual before the program pays for any part of the drug costs.

^‡The amount or portion an individual pays with each prescription filled.

^§Registered residents are defined as residents with valid provincial/territorial health coverage.

^¶All antiretroviral regimens must be authorized by a British Columbia Centre for Excellence physician before medications can be dispensed.

^**In Manitoba, an adjusted total family income is the total taxable income minus $3000 for each dependent under the age of 18 years (www.gov.mb.ca/health/pharmacare/estimator.html).

^††In New Brunswick, a copayment of 20% of the prescription to a max of $20 or $500/family unit/yr with annual registration of $50 is not collected.

^‡‡On Apr. 10, 2018, the government of Saskatchewan announced a change in its reimbursement policy to provide universal coverage for HIV medication to all registered residents. Data presented are those extracted in December 2017.

All other jurisdictions had either a co-payment or a deductible, or both, for antiretrovirals. Quebec also collected a yearly income-based premium of $0 to $667 from noninsured people whether they purchased drugs or not. There was no limit to the annual income-based deductible collected in Manitoba, Newfoundland and Labrador, Ontario and Saskatchewan, and a high income did not disqualify a person from receiving government assistance in any jurisdiction except in Newfoundland and Labrador, where there was no assistance available for a resident with a net annual household income of more than $150 000.

In almost all regions where antiretroviral expenses were shared, fees were reduced or waived for people with very low incomes. Seniors, in contrast, incurred the same out-of-pocket expenses as their non-senior counterparts with the same income in Manitoba and Nova Scotia. Ontario, Quebec, Saskatchewan and Newfoundland and Labrador had multiple programs with eligibility criteria varying according to age, income or drug costs.

The programs also differed in other ways. First, although British Columbia, Alberta, New Brunswick and Prince Edward Island provide antiretrovirals at no cost to their residents, these provinces did not provide universal coverage of prescriptions not related to HIV. Second, coordination of benefits with private insurers was allowed in all programs sharing antiretroviral costs except Quebec. Similarly, patients living in New Brunswick were not eligible for free antiretrovirals from the government if they received any benefits from a private plan, whether the plan was full or partial. Third, there were interprovincial differences in antiretroviral prescribing and dispensing, with 7 jurisdictions (Alberta, British Columbia, New Brunswick, Nova Scotia, Ontario, Saskatchewan and Yukon) and Correctional Service Canada placing restrictions on the prescriber authorizing the regimen and 5 provinces (Alberta, British Columbia, New Brunswick, Nova Scotia and Prince Edward Island) and Correctional Service Canada assigning designated pharmacies to dispense these therapies.

Patient scenarios and calculated costs

The annual cost of single-tablet abacavir/lamivudine/dolutegravir in the Ontario Drug Benefit Formulary was $15 552.⁶ Our first hypothetical case of a single man with an annual income of $39 000 had no out-of-pocket expenses if he lived in Alberta, British Columbia, Northwest Territories, Nunavut, New Brunswick or Prince Edward Island, but he had an annual prescription cost that varied from $45 to $1944 if he resided elsewhere (Figure 1, Appendix 3). Our second hypothetical case, a married woman with about twice the annual household income of the first case, received her medications at no cost in the same 6 regions, incurred the same expense if she lived in Nova Scotia, Yukon and Quebec (although she would have had to pay a higher premium when she filed her higher household tax return) and paid $2720 to $7993 (17% to over 50% of the antiretroviral cost) if she lived in one of the remaining regions (Figures 1 and 2, Appendix 3).

Figure 1:

Estimated annual out-of-pocket costs to purchase single-tablet abacavir/lamivudine/dolutegravir in each jurisdiction, excluding mark-ups and professional fees. The total annual cost of the antiretroviral regimen is $15 552. Case 1 is a single man with no dependents and an annual income of $39 000. Case 2 is a married woman with 2 dependents and an annual net household income of $80 000. Note: AB = Alberta, BC = British Columbia, FED = federal programs, MB = Manitoba, NB = New Brunswick, NL = Newfoundland and Labrador, NS = Nova Scotia, NT = Northwest Territories, NU = Nunavut, ON = Ontario, PE = Prince Edward Island, QC = Quebec, SK = Saskatchewan, YK = Yukon.

Figure 2:

Proportion of annual cost of single-tablet abacavir/lamivudine/dolutegravir paid out-of-pocket. The total annual cost of the antiretroviral regimen is $15 552. Case 1 is a single man with no dependents and an annual income of $39 000. Case 2 is a married woman with 2 dependents and an annual net household income of $80 000. Note: AB = Alberta, BC = British Columbia, FED = federal programs, MB = Manitoba, NB = New Brunswick, NL = Newfoundland and Labrador, NS = Nova Scotia, NT = Northwest Territories, NU = Nunavut, ON = Ontario, PE = Prince Edward Island, QC = Quebec, SK = Saskatchewan, YK = Yukon.

Interpretation

We studied the reimbursement policies of public drug plans in Canada for antiretrovirals. Our main finding was that there is considerable variability across public drug insurance programs for these high-cost drugs, such that a person may incur hundreds or thousands of dollars of additional costs solely on the basis of where they live. Our descriptive analysis showed that this disparity was most striking for high-income earners without private drug insurance. For such people, out-of-pocket expenses would be $0 in 6 regions and could be up to 100% of the antiretroviral cost in jurisdictions with no maximum annual contribution, namely Saskatchewan, Manitoba, Ontario and Newfoundland and Labrador. While the principle of progressivity — that high-income earners should contribute a greater proportion of their income to shared expenditures — is often cited as a criterion for fairness, our cases illustrated that this philosophy has not been universally adopted across the country. Our case of the lower income man paid a greater proportion of his income for antiretrovirals than our woman with a higher income in Nova Scotia, Quebec and the Yukon (Figure 3). However, even among high-income earners enrolled in cost-sharing plans, our analysis revealed there was disparity in the proportion of income used to calculate medication costs and it varied according to where they lived. A person earning more than $75 000 would have a deductible of 6.9% of the family income in Manitoba compared with 4% in Ontario (Table 2). In addition to variability in government subsidies, our analysis found a considerable range of program complexity in terms of eligibility, administration and restrictions placed on providers or dispensing pharmacies. Although we did not evaluate the administrative overhead costs associated with these complexities, others have indicated that considerable cost savings are possible when drug insurance programs are simplified and streamlined.²² The complexity of navigating several programs with differing eligibility criteria and application processes may also prove challenging, especially in specific subgroups of people with HIV, such as people with coexisting cognitive disability or recent immigrants to Canada.

Figure 3:

Proportion of household income needed to purchase single-tablet abacavir/lamivudine/dolutegravir in each jurisdiction. The total annual cost of the antiretroviral regimen is $15 552. Case 1 is a single man with no dependents and an annual income of $39 000. Case 2 is a married woman with 2 dependents and an annual net household income of $80 000. Note: AB = Alberta, BC = British Columbia, FED = federal programs, MB = Manitoba, NB = New Brunswick, NL = Newfoundland and Labrador, NS = Nova Scotia, NT = Northwest Territories, NU = Nunavut, ON = Ontario, PE = Prince Edward Island, QC = Quebec, SK = Saskatchewan, YK = Yukon.

Our finding of heterogeneity in Canada’s public drug programs is consistent with prior work; however, the differences across jurisdictions found in other reviews were attributed to the lack of programs for certain subpopulations, ⁸ drug costs not exceeding the required premiums or deductibles to receive assistance,⁷ or differences in formulary listing.⁹ In contrast, while we found that all jurisdictions listed most antiretrovirals and, with the exception of Newfoundland and Labrador, each had a program to provide coverage for all subpopulations, the main differences in coverage were due to variations in the amount of individual subsidies based on criteria. In 6 jurisdictions, antiretrovirals were fully covered with an HIV diagnosis being the only requirement for eligibility aside from having provincial/territorial health coverage; in the remaining regions, income and age primarily determined the subsidy received. Our results suggest that while the establishment of antiretroviral prescribing programs and formulary listings are necessary conditions for access to coverage, they are insufficient to ensure universal equitable access to antiretrovirals.

Examples of policy options that could address these inequities across the country in eligibility criteria and the value of subsidies include a comprehensive pharmacare program²² or explicit national standards for listing and reimbursing drugs for all age and income groups, perhaps with particular attention to drugs that have implications for public health.²³ For example, medications for tuberculosis and many sexually transmitted infections are universally covered in all or almost all jurisdictions, respectively. On Apr. 10, 2018, the government of Saskatchewan joined 11 jurisdictions and announced it also would provide universal HIV drug coverage to its residents.²⁴ In recent years, Canadian jurisdictions (with the exception of Quebec) have established common mechanisms to make listing recommendations through the Common Drug Review and to conduct price negotiations through the pan-Canadian Pharmaceutical Alliance.²⁵ We believe it is also necessary to have national standards and processes to ensure fair and equal cost-sharing mechanisms across the country.

Limitations

Our study has several limitations. First, we evaluated general reimbursement rules but did not address variations in restrictions for specific antiretrovirals. Second, while we gathered data from government websites that inform the public of all available programs, some information may have been missed as details may have been available only in full policy documents. As we chose only 2 illustrative scenarios, our findings should not be interpreted as being comprehensive (representing all scenarios) or representative (representing the most common scenarios), although we believe they will be relevant for many patients. We did not conduct analyses to determine which reimbursement policies were most prohibitive; this was beyond the scope of our research. Although we solely used the listed drug price from the Ontario Drug Benefit Formulary for our comparison of out-of-pocket expenditures and other jurisdictions may have negotiated higher or lower medication prices resulting in different out-of-pocket costs, the actual price would have no implication for patients in jurisdictions that used only income-based deductibles (e.g., Manitoba, Ontario and Saskatchewan) or capped out-of-pocket payments (e.g., Quebec, Yukon). Our study was also restricted to public antiretroviral coverage for adults; we did not examine reimbursement policies for children and youth. Finally, while we documented inequities in cost-sharing, we did not examine whether these inequities result in financial hardship or negative health outcomes. Exploratory research has suggested antiretroviral-associated costs compete with other essential needs.²⁶ Our group and others have shown that cost-sharing arrangements for antiretrovirals result in substantial numbers of patients who are unable to afford their medications^27,28 and consequently, nonadherence.^12,13

Conclusion

Our study revealed stark inter- and intra-jurisdiction differences for antiretroviral coverage, despite the existence of a public drug plan in each jurisdiction. These disparities result in unequal costs for people living in Canada with identical prescriptions, hindering health equalities across the nation. Addressing cost-sharing inequities may be an important strategy for policy-makers to consider to achieve Canada’s commitment to the final 2 goals of the UNAIDS strategy, in which 90% of all people living with HIV know their HIV status, 90% of all people diagnosed with HIV receive antiretroviral therapy and 90% of all people receiving HIV treatment are virally suppressed by 2020.²⁹