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. Author manuscript; available in PMC: 2018 Dec 3.
Published in final edited form as: Sci Total Environ. 2017 Feb 1;579:1643–1648. doi: 10.1016/j.scitotenv.2016.03.146

Human Health Screening and Public Health Significance of Contaminants of Emerging Concern Detected in Public Water Supplies

Robert Benson 1,*, Octavia D Conerly 2, William Sander 3, Angela L Batt 4, J Scott Boone 5, Edward T Furlong 6, Susan T Glassmeyer 4, Dana W Kolpin 7, Heath E Mash 8, Kathleen M Schenck 8, Jane Ellen Simmons 9
PMCID: PMC6277017  NIHMSID: NIHMS1503201  PMID: 28040195

Abstract

The source water and treated drinking water from twenty five drinking water treatment plants (DWTPs) across the United States were sampled in 2010 – 2012. Samples were analyzed for 247 contaminants using 15 chemical and microbiological methods. Most of these contaminants are not regulated currently either in drinking water or in discharges to ambient water by the U. S. Environmental Protection Agency (USEPA) or other U.S. regulatory agencies. This analysis shows that there is little public health concern for most of the contaminants detected in treated water from the 25 DWTPs participating in this study. For vanadium, the calculated Margin of Exposure (MOE) was less than the screening MOE in two DWTPs. For silicon, the calculated MOE was less than the screening MOE in one DWTP. Additional study, for example a national survey may be needed to determine the number of people ingesting vanadium and silicon above a level of concern. In addition, the concentrations of lithium found in treated water from several DWTPs are within the range previous research has suggested to have a human health effect. Additional investigation of this issue is necessary. Finally, new toxicological data suggest that exposure to manganese at levels in public water supplies may present a public health concern which will require a robust assessment of this information.

Keywords: Drinking Water, Contaminants of Emerging Concern, Human Health, Margin of Exposure

1. Introduction

Water is a necessary component of life. Yet there is a clear recognition that current human use of available fresh water is not sustainable. The presence in drinking water of chemicals derived from human inputs into source water is of increasing public concern with regard to both sustainability and public health. Ideally, the water one consumes should be free of harmful chemical and microbial contaminants. The Safe Drinking Water Act defines “contaminant” as any physical, chemical, biological or radiological substance or matter in water. However, source waters used to produce drinking water often contain both anthropogenic and naturally occurring contaminants. The anthropogenic contaminant load results from the complex interplay of increases in population growth, chemical, consumer product, and pharmaceutical usage per consumer and the number of times a particular unit of water is re-used as it moves through the watershed. While it is technologically possible to remove most contaminants to levels below analytical detection limits, the implementation of the treatment technology required to do so could make the water prohibitively expensive. In addition, the presence of some minerals (e.g., magnesium sulfate, potassium chloride, sodium chloride, calcium chloride, magnesium chloride, and potassium bicarbonate) generally improves the taste of drinking water and their presence is considered beneficial. The goal of the drinking water treatment plant (DWTP) is to provide safe drinking water for humans, which is to reduce the concentrations such that any remaining contaminants do not pose an unacceptable human health risk.

This paper is one of a series of papers13 describing a comprehensive study on the presence, concentrations, and persistence of chemical and microbial contaminants of emerging concern (CECs) in source and treated drinking waters of the United States. This was a joint effort of the U.S. Environmental Protection Agency and the U.S. Geological Survey. A primary goal of this study was to provide information for assessing the potential for human exposure to CECs via drinking water. A secondary goal was to estimate removal efficiency of CECs from source waters by currently used drinking water treatment processes under typical DWTP operating conditions, and thus identify possible compounds or organisms that may be amenable to enhanced reduction or removal. The objective of the analysis reported here is to apply health screening values to the contaminants detected in treated drinking water to assess the potential of the detected contaminants to pose a human health risk from long-term exposure.

2. Experimental (Materials and Methods)

In 2010–2012, USEPA arranged for the collection of paired samples of source and treated water from twenty-five DWTP across the United States (Supporting Information Table 1)1. A goal of this study was to better determine the upper boundary of CEC concentrations, rather than provide a nationwide average, so DWTP selection was skewed towards sample locations with known wastewater outfalls in the source water. Candidate locations were selected based on integrated wastewater and drinking water reports31, locations with and without existing pharmaceutical concentration data32, nomination by USEPA and USGS regional personnel, and DWTP self-nomination. Sites were chosen to maximize geographic range, diversity in disinfectant type used in the treatment process, and drinking water plant production volume. Participation in the study was voluntary.

These water samples were analyzed for 247 chemical and microbial contaminants using 15 chemical and microbial methods. The complete description of the analytical methods, the detection limits, and the concentrations detected in source and treated drinking water for the chemical contaminants are presented elsewhere13. An overview of the analytical methods is provided in Supporting Information Table 2. The focus of the analysis presented here is on Contaminants of Emerging Concern (CECs) detected in treated drinking water in comparison to human health information from long-term exposure to the contaminant. Accordingly, chemicals with existing Maximum Contaminant Levels (MCLs) for drinking water6 were excluded (antimony, arsenic, atrazine, barium, bromate, cadmium, chlorite, chromium, copper, fluoride, lead, nitrate, nitrite, selenium, and uranium). Also excluded from this analysis are select chemicals that are essential nutrients (calcium, chloride, magnesium, phosphorus, potassium, and sodium) and chemicals with reference values based on aesthetic effects (taste and odor) (ammonia and sulfate) rather than adverse health effects. Although iron and zinc are essential nutrients, they are included in this analysis because there is concern for adverse health effects at elevated exposure78. Manganese is included because new information suggests the potential for adverse developmental neurological effects in the range of exposures (100 to 1,000 micrograms/liter) often found in drinking water supplies912.

A variety of perfluorinated chemicals were detected in the treated drinking water of every DWTP. The list of these analytes is in Supporting Information Table 4. However, an analysis of the human health significance from exposure to these chemicals is not presented in this publication. The analysis of the human health significance of exposure to PFSs and PFAs will be reported in a future publication.

Information on health effects for chemicals (expressed as mg/kg body weight per day) was obtained from a variety of sources, including the USEPA Integrated Risk Information System (IRIS) data base8, the USEPA Office of Water Provisional Health Advisories16, the USEPA Superfund Provisional Peer Reviewed Toxicity Value (PPRTV) documents7, the Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profiles14, the USEPA Office of Pesticide Programs Registration Eligibility Decision documents15, the World Health Organization Joint Expert Commission on Food Additives Acceptable Daily Intake (ADI) documents16, the National Sanitation Foundation documents17, and USEPA’s Aggregated Computational Toxicology Resource (ACToR) data base18.

The analysis reported here followed USEPA’s risk assessment methodology as described in IRIS19. Useful background documents found in IRIS under “Guidance and Tools” include “Reference Dose (RfD): Description and Use in Health Risk Assessments” and “A Review of the Reference Dose and Reference Concentration Processes.” The health assessment document for each substance provides information of the toxicity benchmark for the adverse health effect for the substance, that is, the No Observed Adverse Effect Level (NOAEL), the 95% Lower Confidence Limit of the Benchmark Dose (BMDL), or the Lowest Observed Adverse Effect Level (LOAEL) from a long-term toxicity study. Each health assessment document also provides information on the uncertainty factors (UF) used in the assessment. The types of UFs can include uncertainty in extrapolating from a laboratory animal to a human (UFA), uncertainty in extrapolating to the general human population (UFH), uncertainty in extrapolating from a sub-chronic to a chronic exposure (UFS), uncertainty in extrapolating from a LOAEL to a NOAEL (UFL), and uncertainty due to an incomplete data base (UFD). The total UF used in the assessment is chemical specific and depends on the quality and quantity of the toxicological data available.

The margin of exposure (MOE) was used as a screening tool to assess whether or not exposure might present a significant public health concern from long-term exposure to the contaminants detected in treated water. The MOE is a ratio of a toxicity benchmark and an exposure dose. The Drinking Water Equivalent Level (DWEL, mg/L) was calculated from the NOAEL, the BMDL, or the LOAEL and the standard drinking water scenario (80 kg person drinking 2.4 liters of water per day).

DWEL(mg/L)=(NOAEL,BDMLorLOAEL)mg/kg-day×80kg2.4Lwater/day

The MOE for each chemical was then calculated by dividing the DWEL by the concentration detected in the treated drinking water and rounded to two significant digits.

MOE=DWELMeasuredDrinkingWaterConcentration

For purposes of this analysis, the assumption is that drinking water provides 100 percent of the contaminant source contribution. In the absence of contaminant specific data on exposure from other media, a data derived Relative Source Contribution (RSC) cannot be calculated. If a default 20 percent RSC were to be applied, the MOE values would be lower. The calculated MOE was then compared to the MOE screening value. Considerations for selecting the screening MOE for each chemical include the quality and quantity of the toxicological data available for a particular contaminant as reflected in the total UF used in the human health assessment. The screening value for the MOE for the chemicals was assigned as equal to the total uncertainty factor (UF) used in the human health assessment for the particular contaminant7, 1618. Silicon and hexahydrohexamethyl cyclopentabenzopyran (HHCB also known as galaxolide) do not have conventional human health assessments. For these chemicals the MOE screening value of 3,000 was used as this is the maximum total UF allowed by the IRIS Program for a file that is posted on the data base19.

Because of the lack of available toxicity data for the majority of pharmaceuticals, the Maximum Recommended Therapeutic Dose (MRTD) was used to calculate the MOE. The MRTD is an estimated upper dose limit beyond which a drug’s efficacy is not increased and/or undesirable adverse effects begin to outweigh beneficial effects recommended by the Food and Drug Administration to treat targeted patient populations for specific conditions20 and are clearly effect levels in the targeted patient population. These values are readily accessible via the Drugs.com internet database21. It should be noted that these values are developed for the targeted patient population and not for the general population, which includes potentially sensitive populations such as infants, pregnant women, and the immuno-compromised22. For all pharmaceuticals where the MRTD was used to calculate the DWEL, the MOE screening value of 3,000 was used to be consistent with the process of deriving a Health Reference Level from the MRTD in the Contaminant Candidate List process30.

When the calculated MOE is larger than the selected MOE screening value, it is generally considered that exposure to that contaminant has little, if any, public health significance. In contrast, if the calculated MOE is smaller than the selected MOE screening value, then further research may be necessary to decide whether controls to limit exposure are warranted.

3. Results and Discussion

Forty-one CECs were detected one or more times in the treated drinking waters at concentrations greater than their respective Lowest Concentration Minimum Reporting Limit (LCMRL) in this study. MOEs were calculated for twenty-six analytes (three pharmaceuticals lack an adequate toxicity value and the 12 PFCs will be reported separately).

3.1. Assessment of Chemicals Detected in Elemental Analytes Method

The calculated MOE reported in Table 1 is for the water system that had the highest detected level of the particular analyte in the treated drinking water1. Additional details are in Supporting Information Table 3.

Table 1.

MOE for Elemental Analytes

Analyte Toxicity Value (mg/kg-day) Literature Reference for Toxicity Value DWEL (mg/L) Maximum Detected (mg/L) DWTP with Maximum Detection MOE Calculated MOE Screen
Aluminum 100 LOAEL 7 3,333 0.1875 14 18,000 100
Bromide 7 NOAEL 17 233.3 0.24 25 970 10
Chlorate 0.9 BMDL 15 30.00 0.32 27 94 30
Iron 1 LOAEL 7 33.33 0.0907 27 370 1.5
Manganese 0.047 NOAEL 8 1.555 0.0556 18 28 3
Nickel 5 NOAEL 8 166.7 0.0035 4 48,000 300
Silicon 800 NOAEL 18 26,670 22.26 5 1,200 3,000
Strontium 190 NOAEL 8 6,333 0.9996 28 6,300 300
Tin 32 NOAEL 14 1,067 0.0159 24 67,000 100
Vanadium 0.22 NOAEL 7 7.333 0.0049 5 1,500 3,000
Zinc 0.91 NOAEL 8 30.33 0.1002 4 300 3

Vanadium was detected in treated drinking water in only four DWTPs (5, 23, 25, and 28). However, the calculated MOE for vanadium was less than the screening MOE of 3,000 in treatment plants 5 (1,500) and 25 (1,600) and close to the screening MOE in treatment plant 23 (3,200). Thus there is some public health concern for exposure to vanadium from drinking water and further research is necessary to decide whether controls to limit exposure to vanadium are warranted to increase public health protection.

Although the MOE for exposure to manganese is greater than the screening level MOE of 3, there is some potential public health concern from exposure to manganese from drinking water because there is evidence from new toxicological studies912 that the NOAEL in the general adult population could be an effect level for developmental neurotoxicity. However, a systematic review of the available data on manganese has not been conducted and a new NOAEL or LOAEL is not available.

Silicon was detected in the treated water from every DWTP. The calculated MOE for silicon was less than the screening MOE of 3,000 in only one DWTP. However, 14 DWTPs had a calculated MOE between 3,000 and 10,000 as indicated in Supporting Information Table 3. As there is uncertainty in the selected screening MOE due to the poor quality of the toxicity data base for silicon, it would be helpful if additional toxicity data were collected.

3.2. Assessment of Anthropogenic Waste Indicators

USGS Analytical Method 1433 covers a wide variety of chemicals commonly present in wastewater, such as detergent metabolites, fragrances and pesticides, which we collectively refer to as anthropogenic waste indicators (AWIs). The MOE reported in Table 2 is for the water system that had the highest detected level of the particular analyte in the treated drinking water1. Additional details are in Supporting Information Table 3. All of the calculated MOEs are more than 106. These results suggest that exposure to these compounds from drinking water is not likely to pose a public health concern.

Table 2.

MOE for Anthropogenic Waste Indicators

Analyte Toxicity Value (mg/kg-day) Literature Reference for Toxicity Value DWEL (mg/L) Maximum Detected (mg/L) DWTP with Maximum Detection MOE Calculated MOE Screen
Acetophenone 423 NOAEL 8 14,100 580 × 10−6 29 24 × 106 3,000
Hexahydrohexamethyl Cyclopentabenzopyran (HHCB, Galaxolide) 150 NOAEL 18 5,000 61 × 10−6 26 82 × 106 3,000
Isopherone 150 NOAEL 8 5,000 32 × 10−6 2 160 × 106 1,000
Metolachlor 9.7 NOAEL 15 323.3 100 × 10−6 21 3.2 × 106 100
Triethyl citrate 2000 ADI 16 66,670 13 × 10−6 1 5,100 × 106 100

3.3. Assessment of Pharmaceuticals

Some general risk-related conventions to consider when evaluating pharmaceuticals as drinking water contaminants are: 1) for pharmaceuticals, risks of adverse effects are often tolerable in relation to therapeutic benefits whereas, for drinking water contaminants, adverse effects resulting from exposure are undesirable and would be expected to trigger remedial action to reduce exposure; 2) for pharmaceuticals, therapeutic pharmacological effects are expected under conditions of use, whereas for drinking water contaminants, pharmacological effects are to be avoided; and 3) pharmaceuticals are approved and intended for specific patient populations, whereas acceptable drinking water contaminant levels must be considered harmless to the general population25. Therefore, the Maximum Recommended Therapeutic Dose (MRTD) is not an ideal measure to be used when assessing pharmaceuticals as drinking water contaminants. However, in the absence of readily available toxicological data, the MRTD is considered the best available data for the purposes of this analysis. The approach used in this assessment is to consider the MRTD as a LOAEL in the calculation of the MOE and to use a screening MOE of 3,000 when the MRTD was used to derive the DWEL.

Of the 118 pharmaceuticals included in this study, 41 were detected in at least one source water sample. The pharmaceuticals that were detected represent varied modes of action and drug types and are listed in Supporting Information Table 5 by drug type and World Health Organization (WHO) Anatomical Therapeutic Chemical (ATC) Classification System code. Fluconzole and diphenhydramine appear in two different WHO categories, while ibuprofen and lidocaine appear in three different WHO categories. Pharmaceuticals detected in source water can be categorized into 8 ATC categories: alimentary tract and metabolism, cardiovascular system, dermatologicals, genitourinary system and sex hormones, anti-infectives for systemic use, musculoskeletal system, nervous system, and respiratory system (Supporting Information Table 5). However, after the drinking water treatment process, this number diminishes to 5. No pharmaceuticals from 3 ATC categories (alimentary tract and metabolism, dermatologicals or musculoskeletal system) were detected in treated drinking water.

Of the 23 pharmaceuticals detected in treated drinking water, only 13 were detected at concentrations greater than their respective LCMRL or an alternative minimum reporting limit (clofibric acid, lithium, and pseudoephedrine)2. MRTDs were not located for three of these pharmaceuticals (cotinine, sulfamethoxazole, and verapamil). The MOEs for the remaining nine pharmaceuticals were calculated and are listed in Table 3. Progesterone is discussed in Section 3.4, assessment of hormonally active environmental contaminants. The MOE reported in Table 3 is for the water system that had the highest detected level of the particular pharmaceutical in the treated drinking water2. Additional details are in Supporting Information Table 3. The screening MOE for all pharmaceuticals where the DWEL was calculated from the MRTD was 3,000. There is a health assessment for lithium based on a NOAEL7. The screening MOE for lithium was set at 1,000, equal to the total UF used in the assessment. None of the calculated MOEs were less than the screening value. These results suggest that exposure to these pharmaceuticals from drinking water is not likely to pose a public health concern. However, it is still important to note that additional toxicity data are needed and would provide greater confidence in the MOEs calculated for these pharmaceuticals.

Table 3.

MOE for Pharmaceuticals Detected in Treated Drinking Water

Analyte DWTP with Maximum Detection Toxicity Value (mg/kg-day) Reference for Toxicity Value DWEL (mg/L) Maximum Detection (ng/L) MOE Calculated
Bupropion 26 7.5 MRTD 21 250 10.9 23,000,000
Carbamazepine 23 26.7 MRTD 21 890 26.5 34,000,000
Clofibric Acid 14 33.3 MRTD 21 1,110 91.7 12,000,000
Cotinine 4 None - - 15.8 -
Diazepam 4 0.667 MRTD 21 22.23 0.85 26,000,000
Lamivudin 17 5 MRTD 21 166.7 27.7 6,000,000
Lithium 20 2 NOAEL 7 66.67 42,700 1,600
Metoprolol 4 6.67 MRTD 21 223.3 18.4 12,000,000
Propranolol 27 10.7 MRTD 21 356.7 2.5 140,000,000
Pseudoephedrine 27 4 MRTD 21 133.3 3.75 36,000,000
Sulfamethoxazole 5 None - - 8.2 -
Verapamil 21 None - - 26.7 -

Relatively high concentrations of lithium (compared to other pharmaceuticals) were detected in treated drinking water. Lithium was classified as a pharmaceutical in this study because its presence in source and treated waters was inferred to derive in part from lithium excreted as a result of its use as a neuroleptic pharmaceutical. Although it is not possible, based on this study, to determine whether the concentrations of lithium in source water can be apportioned between anthropogenic wastewater discharges (including pharmaceutical use) or naturally occurring lithospheric sources due to the transport of lithium from source to treated water, lithium was conservatively transported through drinking water treatment2. The concentrations of lithium in source and treated drinking water observed in this study are within the range of the concentrations of lithium observed in studies showing a statistically significant inverse association with suicide rates and standardized mortality rations for suicide, suggesting a potential human health effect from this exposure26. Some additional data also suggest a potential for neurodevelopmental effects from prenatal exposure to lithium33, 34. None of this information was included in the health assessment for lithium7. Further research is necessary to decide whether controls to limit exposure to lithium are warranted to increase public health protection.

3.4. Assessment of Hormonally Active Environmental Contaminants

Twelve hormonally active agents were included in this study and are listed in Supporting Information Table 6.

Seven hormonally active agents were detected in source water in the ng/L range. Only progesterone was detected in treated drinking water at a concentration of 0.20 ng/L in one DWTP1. Using the LOAEL of 3.3 mg/kg body weight/day from a study27 used to derive the ADI for progesterone, the calculated MOE is 550 million compared to the screening MOE of 1,000, which indicates that exposure to the concentration of progesterone found in this study is not likely to pose a public health concern.

In a companion effort utilizing samples collected at the same time as those reported in the present paper, Conley et al.3 analyzed the treated drinking water from these 25 plants for three natural estrogens, estrone (E1), 17β-estradiol, (E2), estriol (E3), and one synthetic estrogen, 17α-ethinyl estradiol (EE2). These four compounds, if present in any of the treated water samples, were below the lowest concentration minimum reporting limit. In contrast, in vitro estrogenicity, assessed with the T47D-KBluc assay, was detected in three samples of treated drinking water. When expressed as 17β-estradiol equivalents, the maximum value detected in DWTP 1 was 0.0782 ng/L. Using the NOAEL of 5,000 ng/kg-day from WHO35 to calculate the DWEL, the calculated MOE is 2.10 million compared to a screening MOE of 100, which indicates that exposure to the concentration of estrogenic hormones found in this study is not likely to pose a public health concern. The results from Conley et al.3 highlight the utility of integrated chemical and biological characterization of complex mixtures, as has been demonstrated for environmentally realistic, complex mixtures of disinfection byproducts36, in particular for assessing the components or fractions of the complex mixture associated with toxicity and potential risk37.

4. Future Directions

Because new chemicals and pharmaceuticals are constantly being introduced into commerce, on-going research on the presence of contaminants in drinking water is necessary. In particular it will be important to consider the relative potential human health risk(s) associated with the presence in drinking water of chemical contaminants derived from the source water along with those that may be associated with contaminants formed during disinfection (disinfection byproducts) and those that may be posed by residual microbial (bacterial, viral) contaminants. This will allow risk management and risk remediation efforts to be focused on the greatest potential risks. A potential source for new analytes to be considered for future studies is USEPA’s Contaminant Candidate List30. Further, additional health effects data for some contaminants with limited data would help strengthen the conclusions on the public health significance from exposure to contaminants.

The analysis presented does not consider potential toxicological interactions among the CECs and other contaminants that are present in the treated drinking water from each DWTP. This type of analysis could be conducted in the future.

Supplementary Material

Supplement1

Supporting Information Table 1. Background Information on the DWTPs

Supporting Information Table 2. Overview of Methods

Supporting Information Table 3. Calculated MOEs for Each DWTP

Supporting Information Table 4. Perfluorinated Analytes

Supporting Information Table 5. Pharmaceuticals Detected in Source or Treated Water Listed by WHO ATC Level and Drug Type

Supporting Information Table 6. Hormonally Active Environmental Contaminants Sampled

Disclaimers and Acknowledgements

The authors declare no competing financial interest. The information in this document has been funded partially or wholly by the U.S. Environmental Protection Agency. The research described in this article has been funded in part by the U.S. Environmental Protection Agency through Interagency Agreement DW14922330 to the U.S. Geological Survey, and through programmatic support of the USGS’ Toxic Substances Hydrology Program and the USEPA’s Office of Research and Development, Office of Water, Office of Chemical Safety and Pollution Prevention, and Region 8. Information Collection Rule approval for the Phase II Questionnaire was granted under USEPA ICR No. 2346.01, OMB Control No. 2080–0078. This manuscript has been subjected to review by the USEPA National Health and Environmental Effects Research Laboratory and by the USEPA Office of Water and approved for publication. Approval does not signify that the contents reflect the views of the USEPA and mention of trade names or commercial products does not constitute endorsement or recommendation for use by USEPA. This document has been reviewed in accordance with USGS policy and approved for publication. Any use of trade, firm, or product names is for descriptive purposes only and does not imply endorsement by the U.S. Government. The authors would like to thank all participating DWTPs for their involvement in the project and for their assistance in collecting the samples.

Abbreviations

ACToR

Aggregated Computational Toxicology Resource

ADI

Acceptable Daily Intake

ATC

Anatomical Therapeutic Chemical

ATSDR

Agency for Toxic Substances and Disease Registry

AWI

Anthropogenic Waste Indicator

BMDL

Lower 95% Confidence Limit of the Benchmark Dose

CECs

Contaminants of Emerging Concern

DSSTox

Distributed Structure-Searchable Toxicity Database Network

DWEL

Drinking Water Equivalent Level

DWTP

Drinking Water Treatment Plant

E1

Estrone

E2

17β-Estradiol

E3

Estriol

EE2

17α-Ethinyl estradiol

HHCB

Hexahydrohexamethyl Cyclopentabenzopyran

IRIS

Integrated Risk Information System

LCMRL

Lowest Concentration Minimum Reporting Limit

LOAEL

Lowest Observed Adverse Effect Level

MCL

Maximum Contaminant Level

MOE

Margin of Exposure

MRTD

Maximum Recommended Therapeutic Dose

NOAEL

No Observed Adverse Effect Level

PFAs

Perfluorinated Acids

PFOA

Perfluorooctanoic Acid

PFOS

Perfluorooctanesulfonic Acid

PPRTV

Provisional Peer Reviewed Toxicity Value

PFSs

Perfluorinated Sulfonic Acids

RfD

Reference Dose

RSL

Relative Source Contribution

UF

Uncertainty Factor

USEPA

U. S. Environmental Protection Agency

USGS

U. S. Geological Survey

WHO

World Health Organization

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplement1

Supporting Information Table 1. Background Information on the DWTPs

Supporting Information Table 2. Overview of Methods

Supporting Information Table 3. Calculated MOEs for Each DWTP

Supporting Information Table 4. Perfluorinated Analytes

Supporting Information Table 5. Pharmaceuticals Detected in Source or Treated Water Listed by WHO ATC Level and Drug Type

Supporting Information Table 6. Hormonally Active Environmental Contaminants Sampled

RESOURCES