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. 2018 Oct 13;46(21):11656–11657. doi: 10.1093/nar/gky979

Novel diagnostic tool for prediction of variant spliceogenicity derived from a set of 395 combined in silico/in vitro studies: an international collaborative effort

Raphaël Leman 1,2,3,3,4, Pascaline Gaildrat 2,3,4, Gérald L Gac 4, Chandran Ka 4, Yann Fichou 4, Marie-Pierre Audrezet 4, Virginie Caux-Moncoutier 5,6,7,4, Sandrine M Caputo 7,3,4, Nadia Boutry-Kryza 8,4, Mélanie Léone 8,4, Sylvie Mazoyer 9,3,4, Françoise Bonnet-Dorion 10,4, Nicolas Sevenet 10,4, Marine Guillaud-Bataille 11,4, Etienne Rouleau 11,4, Brigitte Bressac-de Paillerets 11,4, Barbara Wappenschmidt 12,3, Maria Rossing 13,4, Danielle Muller 14,4, Violaine Bourdon 15,3, Françoise Revillon 16,4, Michael T Parsons 17,3, Antoine Rousselin 1,2,4, Grégoire Davy 1,2,4, Gaia Castelain 2,4, Laurent Castéra 1,2,4, Joanna Sokolowska 18,4, Florence Coulet 19,4, Capucine Delnatte 20,4, Claude Férec 4, Amanda B Spurdle 17,3, Alexandra Martins 2,3,4, Sophie Krieger 1,2,3,✉,2,3,4,5, Claude Houdayer 5,6,7,✉,2,3,4,6
PMCID: PMC6277085  PMID: 30321405

Nucleic Acids Research, gky372, https://doi.org/10.1093/nar/gky372

In their article, the authors use HSF version 2.4 instead of HSF version 3.1 which is not imbedded in the Alamut software. To check whether HSF3.1 performed better than SPiCE, the authors have run HSF3.1 on the same training and validation datasets, using the methodology previously described in the published article.

The authors acknowledge that HSF3.1 does indeed perform better than HSF 2.4. However the new analyses confirm that SPiCE remains the best predictor of consensus elements.

The comparison between HSF 2.4, HSF3.1 and SPiCE and the underlying data are available as supplementary material.

Supplementary Material

Supplementary Data
Click here for additional data file. (275.6KB, zip)

SUPPLEMENTARY DATA

Supplementary Data are available at NAR Online.

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Data
Click here for additional data file. (275.6KB, zip)

Articles from Nucleic Acids Research are provided here courtesy of Oxford University Press

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