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. 2018 Sep 12;12(3-4):245–252. doi: 10.1080/19336896.2018.1513316

Figure 4.

Figure 4.

Comparison of amino acid sequences of prion protein in human, mouse, sheep, goat, dog, rabbit and horse. Prion protein sequences were obtained from GenBank at the National Center for Biotechnology Information (NCBI), including those of human (Homo sapiens, BAG32277.1), mouse (Mus musculus, NP_001265185.1), sheep (Ovis aries, NP_001009481.1), goat (Capra hircus, NP_001301176.1), dog (Canis lupus familiaris, ACO71291.1), rabbit (Oryctolagus cuniculus, NP_001075490.1) and horse (Equus caballus, NP_001137270.2). A. Protein sequences were aligned using ClustalW2 based on progressive alignment methods. Colors indicate the chemical properties of amino acids; blue: acidic; red: small and hydrophobic; magenta: basic; green: hydroxyl, sulfhydryl, amine and glycine. The arrow indicates the polymorphism. Asterisks indicate horse-specific residues. B. Protein sequences were aligned using Wasabi based on phylogeny-aware methods. Colors were followed ‘Taylor color’. The arrow indicates the polymorphism. Asterisks indicate horse-specific residues.