Table 2.

Polyphenol-loaded polymeric micelles for the treatment of cancer.

No.	Components of Nanoparticles	Method of Preparation	Polyphenol + Synergistic Agent	Type of Cancer In Vitro Model/In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation	References
1	Gelatin–Dextran	Self-assembly-Genipin-Crosslinking	Plant polyphenols	Breast cancer MCF-7	[26]
2	Gelatin–Dextran	Self-assembly-Genipin-Crosslinking	Curcumin	Cervical cancer HeLa Healthy mice	[27]
3	Casein	Self-assembly	Curcumin	Cervical cancer HeLa	[32]
4	Zein–PEG	Self-assembly	Curcumin	Ovarian cancer NCI Healthy mice	[33]
5	Chitosan–Stearic acid	Self-assembly	Curcumin	Colon cancer Primary Xenograft mice	[34]
6	PEG–Polyanhydride esters	Solvent evaporation	Curcumin	Cervical cancer HeLa	[35]
7	PEG–Polylactic acid	Solvent evaporation	Curcumin + Doxorubicin	Breast cancer MCF-7 Xenograft mice	[36]
8	PEG–Polycaprolactone	Thin-layer evaporation	Curcumin	Ovarian cancer A2780t	[38]
9	PEG–Polycaprolactone	Thin-layer evaporation	Curcumin	Breast cancer MDA-MB-436	[37]
10	PEG–Polycaprolactone	Self-assembly	Curcumin	Breast cancer 4T1–4T1 Xenograft mice	[40]
11	PEG–Polycaprolactone	Thin-layer evaporation	Curcumin	Cervical cancer HeLa Xenograft mice	[39]
12	PEG–Polycaprolactone	Thin-layer evaporation	Curcumin	Colon HT-29	[39]
13	PEG–Polycaprolactone	Thin-layer evaporation	Curcumin + Doxorubicin	Lung cancer LL/2 Xenograft mice	[41]
14	Linoleic acid-PEG-Polycaprolactone	Self-assembly	Curcumin	Cervical cancer HeLa Healthy mice	[43]
15	Linoleic acid-PEG-Polycaprolactone	Self-assembly	Curcumin	Lung A549	[43]
16	PEG -Palmitic acid	Self-assembly	Curcumin	Cervical cancer HeLa	[32]
17	PEG2000-DSPE	Thin-layer evaporation	Curcumin + Paclitaxel	Ovarian cancer SK-OV-3TR	[45]
18	PEG2000-DSPE	Thin-layer evaporation	Curcumin + Paclitaxel	Ovarian cancer NCI SK-OV-3TR Xenograft mice	[46]
19	PEG2000-DSPE	Thin-layer evaporation	Curcumin + Doxorubicin	Colon cancer HCT-116 Xenograft mice	[44]
20	PEG- Doxorubicin	Self-assembly	Curcumin + Doxorubicin	Cervical cancer HeLa HepG2 Xenograft mice	[47]
21	PEG-Doxorubicin	Self-assembly	Curcumin + Doxorubicin	Hepatic HepG2	[47]
22	Poloxamers F127 F68	Thin-layer evaporation	Curcumin	Cervical cancer HeLa	[48]
23	Poloxamers-PEG-Succinate	Solvent evaporation	Curcumin	Ovarian cancer NCI	[49]
24	Poloxamers F127	Thin-layer evaporation	Resveratrol, Curcumin + Doxorubicin	Ovarian cancer SKOV-3 Healthy mice	[50]
25	Poloxamers F127	Thin-layer evaporation	Resveratrol, Quercetin + Doxorubicin	Ovarian cancer SKOV-3 Healthy mice	[31]
26	Apolipoprotein-E3	recombinant DNA	Resveratrol	Glioblastoma A-172	[51]
27	Polycaprolactone-PEG-Succinate	Thin-layer evaporation	Resveratrol	Breast cancer MCF-7	[52]
28	Casein	Self-assembly	Epigallocatechin gallate	Colon cancer HT-29	[53]
29	Polylactic acid-PEG	Thin-layer evaporation	Epigallocatechin gallate	Pancreatic cancer MiaPaca-2	[54]

Note: PEG2000-DSPE—1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxypolyethylene glycol-2000].