Table 4.

Polyphenol-loaded polymeric nanoparticles for the treatment of cancer in vitro.

No.	Components of Nanoparticles	Method of Preparation	Polyphenol + Synergistic Agent	Type of Cancer In Vitro Model In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation	References
1	Gelatin–Polyelectrolyte	Layer-by-layer	Epigallocatechin gallate	Breast cancer MBA-MD-231	[81]
2	PLGA–PEG	Nanoprecipitation	Epigallocatechin gallate	Prostate cancer LNCaP	[82]
3	Casein-phospho-peptide–Chitosan	Genipin-Crosslinking	Epigallocatechin gallate	Hepatic cancer HepG2	[83]
4	Casein-phospho-peptide–Chitosan	Genipin-Crosslinking	Epigallocatechin gallate	Gastric cancer BGC823	[83]
5	Casein-phospho-peptide–Chitosan	Genipin-Crosslinking	Epigallocatechin gallate	Colon cancer Caco-2	[84]
6	Hyaluronic acid	Self-assembly	Epigallocatechin gallate + Doxorubicin	Cancer of the external auditory canal	[85]
8	Chitosan	Ionic gelation	Epigallocatechin gallate	Prostate cancer 22R_1 Xenograft mice	[87]
7	Chitosan	Ionic gelation	Epigallocatechin gallate	Melanoma Mel928 Mel928 Xenograft mice	[88]
9	Chitosan–Gelatin–PEG	Ionic gelation	Epigallocatechin gallate	Gastric cancer Luc MKN45 Xenograft mice	[88]
10	PLGA	Nanoprecipitation	Epigallocatechin gallate + Cisplatin	Lung cancer A549	[89]
11	PLGA	Nanoprecipitation	Epigallocatechin gallate + Cisplatin	Cervical cancer HeLA	[89]
12	PLGA	Nanoprecipitation	Theaflavin	Leukemia THP-1	[89]
13	PLGA	Solvent evaporation	Epigallocatechin gallate + Cisplatin	Lung cancer A549 Ehrlich ascites carcinoma Xenograft mice	[90]
14	PLGA	Solvent evaporation	Epigallocatechin gallate	Cervical cancer HeLA	[90]
15	PLGA	Solvent evaporation	Theaflavin	Leukemia THP-1	[90]
16	PLGA	Solvent evaporation	Theaflavin	Cancer of the external auditory canal	[90]
17	PLGA–PEG	Nanoprecipitation	Resveratrol	Prostate cancer DU-145, LNCaP	[91]
18	Bovine serum albumin	Nanoprecipitation	Resveratrol	Lung cancer NCI-H460	[92]
19	Bovine serum albumin	Nanoprecipitation	Resveratrol	Ovarian cancer SKOV3	[93]
20	PLGA	Emulsion method	Resveratrol	Breast cancer MCF-7	[94]
21	Maleimide–PEG–Polylactic acid	Self-assembly	Resveratrol	Glioblastoma CT26, U87 CT26 Xenograft mice	[95]
22	Chitosan	Ionic gelation	Quercetin + 5-fluorouracil	Pancreas cancer MiaPaCa2	[96]
23	PLGA	Emulsion solvent evaporation	Quercetin + Tamoxifen	Breast cancer MCF-7 Xenograft mice	[97]
24	PLGA	Emulsion solvent evaporation	Quercetin + Tamoxifen	Colon cancer Caco2	[97]
25	Hyaluronic acid–Polybutyl cyanoacrylate–a-Tocopheryl–PEG–Succinate	Radical polymerization	Morin hydrate	Lung cancer A549 S180 Xenograft mice	[98]
26	Hyaluronic acid–Polybutyl cyanoacrylate –Tocopheryl–PEG–Succinate	Radical polymerization	Morin hydrate	Hepatic cancer L02	[98]