Table 5.
Polyphenol-loaded polymeric conjugates for the treatment of cancer.
| No. | Components of Nanoparticles | Method of Preparation | Polyphenol + Synergistic Agent | Type of Cancer In Vitro Model In Vivo Model Promisingly Treated with the Fabricated Nanotherapeutic Formulation | References |
|---|---|---|---|---|---|
| 1 | PEG | Condensation method | Curcumin | Glioma C6 | [106] |
| 2 | PEG | Condensation method | Curcumin | Prostate cancer PC-3 | [105] |
| 3 | PEG | Condensation method | Curcumin + Gemcitabine | Pancreatic cancer MiaPaCa2, PANC-1, BxPC-3, AsPC-1 | [104] |
| 4 | PEG | Condensation method | Resveratrol + Bicalutamide | Cervical cancer HeLa | [107] |
| 5 | PEG | Condensation method | Resveratrol + Bicalutamide | Breast cancer MCF-7 | [107] |
| 6 | Carboxymethyl chitosan | Condensation method | Quercetin + Paclitaxel | Hepatic cancer HepG2 HepG2 Xenograft mice | [108] |
| 7 | PEG | Condensation method | Curcumin | Cervical cancer HeLa, Breast cancer EMT6 EMT6 Xenograft mice | [109] |
| 8 | PEG–Desaminotyrosyl-tyrosine ethyl ester | Condensation method | Curcumin | Breast cancer MDA-MB-231 | [110] |
| 9 | PEG | Condensation method | Catechin + Bortezomib | Breast cancer MDA-MB-231 | [111] |
| 10 | Hyaluronic acid–Polyethyleneimine | Condensation method | Epigallocatechin gallate + Granzyme B | Colon cancer HCT-116 | [112] |
| 11 | Dextran | Free radical grafting | Catechin | Pancreatic cancer MiaPaca-2, PL45 | [113] |
| 12 | Dextran | Free radical grafting | Catechin | Neuroblastoma IMR-32, IMR-32-CisRes, BE2-C Xenograft mice | [114] |
| 13 | Dextran | Enzyme laccase catalysis | Catechin | Neuroblastoma IMR-32 | [114] |
| 14 | Polymethacrylic acid | Free radical grafting | Quercetin | Cervical cancer HeLa | [115] |
| 15 | Gelatin | Free radical grafting | Gallic acid | Prostate cancer DU-145, PC-3 | [116] |
| 16 | Gelatin | Free radical grafting | Gallic acid | Renal cancer A498 | [116] |