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. 2018 Oct 25;23(11):2768. doi: 10.3390/molecules23112768

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© 2018 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Sterolomic identification of ergosterol biosynthesis inhibitors (EBIs) in fungi. Red arrows signify increase or decrease in sterols within the profile of inhibited cultures relative to non-inhibited cultures. (a) Oxazole amidoester-treated cultures of C. albicans decrease in ergosterol and increase in lanosterol and by-products obtusifoliol and eburicol, indicating disruption of 14-SDM activity [77,78]. (b) Posaconazole-treated cultures of Rhizopus arrhizus decrease in ergosterol and ergosta-5,7-dienol and increase in lanosterol, obtusifoliol, and eburicol, and produce toxic 14-methylergosta-8,24(28)-dien-3β,6α-diol [79]. (c) ent-Isoalantolactone-treated cultures of C. albicans decrease in ergosterol and increase in lanosterol and zymosterol, indicating disruption of 24-SMT activity [80].