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. 2018 Jul 30;7(12):e1474318. doi: 10.1080/2162402X.2018.1474318

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Pretreatment frequencies of nTregs correlated with overall survival in mesothelioma patients treated with DC/mCTX-based immunotherapy. A. To determine whether pretreatment frequencies of total Tregs (the percentage of nTregs and aTregs of total CD4 T cells), aTregs or nTregscorrelated with survival in mesothelioma patients treated with DC/mCTX-based immunotherapy, linear regression was performed. No significant correlation was observed between total Tregs (A, left) or aTregs (A, middle) and survival. Linear regression showed a significant positive correlation between pretreatment nTreg frequencies and survival (A, left). B. To determine whether patients with lower pretreatment nTreg frequencies (below 2% of total CD4 T cells, n = 5) had a different survival from patients with higher nTreg frequencies (above 2% of total CD4 T cells, n = 5), survival analysis was performed. Patients with a nTreg percentage above 2% of CD4 T cells, had a better overall survival. Statistical analysis was performed by log-rank (Mantel-Cox) testing, and differences were considered significant when p < 0.05.