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. 2018 Nov 20;7:1819. [Version 1] doi: 10.12688/f1000research.16678.1

Figure 5.

Figure 5.

( a) Representative histopathology section of a traumatic oral ulcer showing an area of intact oral epithelium (OE) which was positively stained for TLR2. Mononuclear inflammatory cells (red arrows) in the connective tissue are also stained brown (TLR2 Immunohistochemistry x400), ( b): Representative histopathology section from a periapical granuloma showing numerous mononuclear inflammatory cells stained brown (red arrows), demonstrating TLR2 expression (TLR2 Immunohistochemistry x400), ( c) Representative histopathology section from a periapical granuloma showing TLR2+ immunostaining on numerous mononuclear inflammatory cells (red arrows) as well as interspersed odontogenic epithelium (E) (TLR2 Immunohistochemistry x400), ( d) Image of TLR2+ cells resembling immune cells of lymphoid lineage under high power magnification (red arrows). Note the cell membrane and cytoplasm are stained brown (TLR2 Immunohistochemistry x1000), ( e) High power magnification of a periapical granuloma histopathology section showing large foamy TLR2+ cells resembling macrophages (red arrows). Note that the neutrophils (black arrows), characterised by multi-lobed nuclei, were negative to TLR2 immunostaining (TLR2 Immunohistochemistry x1000).