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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Cerebellum. 2018 Oct;17(5):590–600. doi: 10.1007/s12311-018-0951-4

Figure 5. Changes in activity of Purkinje cells induced by injection of harmaline in 9 months old and 12 months old wild type and SCA2-58Q mice.

Figure 5

(A, B) Examples of PC firing activity 40 min after 15 mg/kg harmaline IP injection in 9 month old (A) and 12 month old (B) wild type (left) and SCA2-58Q (right) mice. Recording traces of 5 sec in duration with enlarged 100-ms fragment are shown. Complex spikes are marked by filled circles.

(C–E) Effects of harmaline injection on PC activity pattern in 9 months old and 12 months old wild type (n = 6 and n = 6 cells; m = 6 and m = 6 mice accordingly) and SCA2-58Q mice (n = 7 and n = 5 cells; m = 7 and m = 5 mice accordingly). The CS firing frequency (C), SS firing frequency (D) and post-CS pause (E) for each cell were determined 40 min after injection of harmaline and normalized to the same parameters of the same cell recorded before injection of harmaline. Normalized data were averaged and presented as mean ± SE. *P < 0.05, **P < 0.01.