. 2017 Dec 14;159(2):1159–1171. doi: 10.1210/en.2017-00582

Table 1.

Responsiveness of THAI #4, 23, and 18 Mouse Lines to T4

Tissue	THAI #4 (T4)				THAI #23 (T4)				THAI #18 (T4)
Tissue	Eu (RLU/mg Protein)	Hyper (RLU/mg Protein)	Fold (Means ± SEM)	P Value	Eu (RLU/mg Protein)	Hyper (RLU/mg Protein)	Fold (Means ± SEM)	P Value	Eu (RLU/mg Protein)	Hyper (RLU/mg Protein)	Fold (Means ± SEM)	P Value
Pit	0.337	0.791	2.3 ± 0.16	0.0001^a	1.932	16.926	8.8 ± 0.62	0.0001^a	0.066	0.54	8.2 ± 0.36	0.0001^a
MBH	0.206	0.368	1.8 ± 0.20	0.013^a	0.142	0.24	1.7 ± 0.29	0.103	0.372	0.602	2.2 ± 0.25	0.005^a
HC	0.06	0.116	1.9 ± 0.03	0.0001^a	0.035	0.047	1.5 ± 0.35	0.201	2.308	3.756	2.1 ± 0.25	0.013^a
HT	0.377	0.488	1.3 ± 0.08	0.031^a	0.65	0.78	1.2 ± 0.11	0.176	0.755	1.589	2.8 ± 0.35	0.004^a
CTX	0.194	0.359	1.9 ± 0.30	0.035^a	0.179	0.253	1.4 ± 0.13	0.017^a	1.617	2.586	1.9 ± 1.18	0.005^a
CER	0.938	2.162	2.3 ± 0.41	0.019^a	0.012	0.023	1.9 ± 0.28	0.045^a	0.045	0.063	1.8 ± 0.31	0.073
Liver	0.002	0.005	1.9 ± 0.14	0.0007^a	0.001	0.003	2.9 ± 0.86	0.064	No detectable expression
Heart	0.004	0.03	8.5 ± 0.31	0.0001^a	0.001	0.001	1.0 ± 0.25	–	No detectable expression
BAT	0.028	1.82	64.6 ± 8.1	0.0002^a	0.005	0.038	7.2 ± 1.54	0.007^a	No detectable expression
Bone	0.031	0.066	2.2 ± 0.18	0.0015^a	0.01	0.011	0.7 ± 0.11	0.057	No detectable expression
Muscle	0.025	0.276	11.2 ± 5.7	0.0041^a	0.004	0.003	0.7 ± 0.18	0.115	No detectable expression
MSG	0.052	0.399	7.6 ± 2.60	0.044^a	0.004	0.011	2.7 ± 0.77	0.072	Not determined
Thyroid	0.115	0.176	1.5 ± 0.07	0.002^a	0.026	0.03	0.8 ± 0.18	0.734	Not determined
Testicle	4876	4086	0.8 ± 0.06	0.108	2909	2509	0.9 ± 0.11	0.253	Not determined
Intestine	4.571	9.48	2.1 ± 0.30	0.012^a	0.041	0.212	5.2 ± 1.6	0.029^a	Not determined
Skin	0.696	2.798	4.0 ± 0.76	0.001^a	2.358	1.878	0.8 ± 0.17	0.544	Not determined

Euthyroid animals were treated with L-T4 (IP 5 μg/d per animal for 3 days). Luciferase activity was assessed in tissue samples with luciferase assay and expressed as RLU per milligram protein. Luciferase activity of corresponding tissues of TH vs vehicle-treated animals was performed by Student t test (n ≥ 4).

Abbreviations: CER, cerebellum; CTX, cerebral cortex; Eu, euthyroid; HC, hippocampus; HT, hypothalamus; Hyper, hyperthyroid; MBH, mediobasal hypothalamus; MSG, mandibular salivary gland; Pit, pituitary.

^{^a}

P < 0.05.