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. 2018 Oct 10;156(1):56–68. doi: 10.1111/imm.12998

Figure 2.

Figure 2

Glycometabolism in tumor‐infiltrating B cells decelerates and correlates with the decrease of IgG‐producing B cells in tumor. (a) Levels of LDH, PKM2 and PGK‐1 in CD19+ B cells in adjacent normal sites or tumor sites in the colon tissues of colorectal cancer (CRC) mice at stage T3. (b) FACS analysis of LDH, PKM2 and PGK‐1 levels in CD19+ B cells in colon tissues from CRC mice at stage T1 or T3. (c) FACS analysis of LDH, PKM2 and PGK‐1 levels in IgG‐producing (IgG1+) B cells/without IgG production (IgG1−), as well as in IgG2a+/IgG2a− B cells in the colon tissues from CRC mice at stage T3. (d) Glucose concentrations in adjacent normal sites and tumor sites in the colon tissues from CRC mice at stage T3. (e) Glucose concentrations in the colon tissues from CRC mice at stage T1 and stage T3. All the data shown are pooled from three independent experiments each with 3–4 mice and expressed as mean ± SEM. *P < 0·05, **P < 0·01, ***P < 0·001, ****P < 0·0001.