Fig. 2.

Markedly elevated urate in UOx gKO mice is not associated with BP changes. (a) HPLC analysis of serum urate levels in UOx gKO and WT mice. (b) Invasive SBP versus serum urate of UOx gKO and WT mice at baseline (WT: r²=0·007, p=0·85; UOx gKO: r²=0·012, p=0·38; pooled: r²=0·10, p=0·24). Invasive SBP (c) and HR (D) measurement before (baseline) and after vehicle (saline), 3·3 μg/kg, and 10 μg/kg NOC-9 administration. n=8 and 7, male nine-month old UOx gKO and littermate WT mice. ***p<0·001.