PSX-20 Evaluation of the effectiveness of an anti-mycotoxins additive, to reduce toxic effects on weaned pigs, when consuming feed contaminated with deoxynivalenol.

Abstract

Deoxynivalenol (DON), a mycotoxin belonging to the group of trichothecenes. The main effects of dietary exposure of animals to DON are weight gain suppression, anorexia and altered nutritional efficiency. Therefore, the objective of the study was to evaluate the efficacy of an anti-mycotoxin additive to reduce the toxic effects of weaned pigs after consuming food contaminated with 3,200 μg/kg of DON (21 days). 48 weaned pigs were selected and divided in three treatments of 2 pigs with 8 repetitions and one of the diets was assigned: T1 negative control group, without DON; T2 positive control group, contaminated with DON; T3 challenge group, with 1.5 kg/t of the anti-mycotoxins additive and DON. The piglets were weighed at the beginning of the experiment (28 days of age) and later each week until the end of the experiment. Blood samples were obtained for hematic biometry, hepatic and renal profiles. The information obtained was analyzed by the Tukey test where the significance value was based on 0.05 probability. From the 14 and 21 days of experimentation, there were statistically significant differences between treatments in weight gain, feed intake and concentration of the glutamyl transferase enzyme serum. Intestinal integrity was affected in the DON group. The results obtained show that in the DON present in the diet of the intoxication group affected the consumption of food and consequently the weight gain. The additive used at a rate of 1.5 kg/t feed for this experiment had a protective effect on the weight gain of 71%.