Fig. 4.

Duration of leukopenia. Duration of critical leukopenia (<1.000 leukocytes/µl) in all patients (a), in patients younger than <60 years (b), in patients older than ≥60 years (c). Duration of critical leukopenia was calculated from the start of therapy until recovery of peripheral blood counts and was presented as inverse Kaplan–Meier curves. In (c) please note the “bump” in the standard group (blue line), which is due to the fact that one subgroup of patients received only one cycle of HAM (positive selection because of adequate blast clearance in the day 16 bone marrow aspirate) and the other subgroup received two cycles of HAM (negative selection because of residual blasts in the day 16 bone marrow aspirate). Comparison of the duration of critical leukopenia (<1.000 leukocytes/µl) of all S-HAM patients older than ≥60 years versus those standard arm patients who received only one cycle of HAM (positive selection because of adequate blast clearance in the day 16 bone marrow aspirate) (d), of all S-HAM patients older than ≥60 years versus those standard arm patients who received two cycles of HAM (negative selection because of residual blasts in the day 16 bone marrow aspirate) (e)