Figure 3.

The proposed full-automated infant rs-fMRI processing pipeline. The pipeline is recommended to process BCP rs-fMRI data, which uses an HCP-style rs-fMRI protocol with high spatial and temporal resolutions. There are three modules in the pipeline: minimal preprocessing (A), extensive preprocessing (B), and post-processing (C). During minimal preprocessing, the flow of spatial registration can be combined into a single deformation field and directly used to warp raw infant rs-fMRI data (D). DOF: degree of freedom; DMF: deformation field; SE: spin echo; AP/PA: phase-encoding direction from anterior to posterior and that with the opposite direction; MB: multiband; SB: single-band (traditional EPI); Ref-Img: single-band, single volume EPI data used as a reference during the spatial registration; BBR: boundary-based registration; ICA-FIX, FLIRT, and TOPUP are all the functions in FSL; Labeled Img: segmented anatomical image with each voxel labeled as grey matter, white matter, or cerebrospinal fluid. See main text for details.