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. 2018 Oct 2;13(8):866–874. doi: 10.1080/15592294.2018.1521222

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© 2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 4. — Examples of significant age-varying CpG sites. a) The methylation levels of cg21585707 decreased with age while methylation variability increased with age. b) Both methylation level and methylation variability of cg05666820 increased with age. c) The methylation variability of cg03689146 increased with age but age-associated changes were not detected. d) The methylation variability of cg06464078 decreased with age, and was also identified as a methylation quantitative trait loci site (associated with a genetic variant).