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DMRs in APC-mutation-negative tumors cluster with adjacent normal tissue relative to APC-mutation-positive tumors. (A) Heatmap from unsupervised cluster analysis of the top 200 most variable DMRs in the six APC-mutation-positive and five APC-mutation-negative CRCs from the CCCC. (B) Unsupervised cluster analysis using the same 200 most variable DMRs in 15 APC-mutation-positive and 29 APC-mutation-negative CRCs from the TCGA.
