Table 2.
CCCC AA CRC | TCGA NWH CRC | |||||||
---|---|---|---|---|---|---|---|---|
Arm | Gain frequency | Loss frequency | Gain frequency | Loss frequency | Gain difference1 | Gain P value2 | Loss difference3 | Loss P value2 |
1p | 0 | 0.15 | 0.03 | 0.19 | 0.03 | 0.6 | 0.04 | 0.81 |
1q | 0.09 | 0.03 | 0.17 | 0.1 | 0.08 | 0.32 | 0.07 | 0.34 |
2p | 0.09 | 0 | 0.08 | 0.03 | −0.01 | 0.74 | 0.03 | 0.6 |
2q | 0.12 | 0 | 0.1 | 0.03 | −0.02 | 0.76 | 0.03 | 0.6 |
3p | 0.03 | 0 | 0.06 | 0.09 | 0.03 | 1 | 0.09 | 0.09 |
3q | 0 | 0 | 0.10 | 0.05 | 0.10 | 0.05 | 0.05 | 0.37 |
4p | 0 | 0.3 | 0.01 | 0.25 | 0.01 | 1 | −0.05 | 0.53 |
4q | 0 | 0.33 | 0.04 | 0.24 | 0.04 | 0.61 | −0.09 | 0.29 |
5p | 0.06 | 0.09 | 0.14 | 0.10 | 0.08 | 0.28 | 0.01 | 1 |
5q | 0 | 0.12 | 0.07 | 0.17 | 0.07 | 0.24 | 0.05 | 0.62 |
6p | 0.15 | 0.09 | 0.14 | 0.07 | −0.01 | 0.79 | −0.02 | 0.72 |
6q | 0.06 | 0.12 | 0.14 | 0.10 | 0.08 | 0.28 | −0.02 | 0.76 |
7p | 0.33 | 0 | 0.47 | 0.01 | 0.14 | 0.14 | 0.01 | 1 |
7q | 0.27 | 0.06 | 0.41 | 0.01 | 0.14 | 0.18 | 0.05 | 0.1 |
8p | 0 | 0.33 | 0.28 | 0.50 | 0.28 | 6 × 10 −5 | 0.17 | 0.09 |
8q | 0.12 | 0 | 0.46 | 0.12 | 0.34 | 1 × 10 −4 | 0.12 | 0.03 |
9p | 0.03 | 0.03 | 0.18 | 0.08 | 0.15 | 0.02 | 0.05 | 0.49 |
9q | 0 | 0.03 | 0.15 | 0.09 | 0.15 | 0.01 | 0.06 | 0.33 |
10p | 0 | 0.18 | 0.05 | 0.09 | 0.05 | 0.37 | −0.09 | 0.12 |
10q | 0 | 0.12 | 0.02 | 0.13 | 0.02 | 1 | 0.01 | 1 |
11p | 0.15 | 0.03 | 0.09 | 0.09 | −0.06 | 0.34 | 0.06 | 0.33 |
11q | 0.09 | 0.06 | 0.07 | 0.11 | −0.02 | 0.72 | 0.05 | 0.55 |
12p | 0.12 | 0.03 | 0.21 | 0.09 | 0.09 | 0.35 | 0.06 | 0.33 |
12q | 0.06 | 0.03 | 0.18 | 0.07 | 0.12 | 0.13 | 0.04 | 0.71 |
13q | 0.27 | 0 | 0.56 | 0.04 | 0.29 | 0.003 | 0.04 | 0.61 |
14q | 0.03 | 0.27 | 0.05 | 0.30 | 0.02 | 1 | 0.03 | 0.84 |
15q | 0 | 0.27 | 0.02 | 0.32 | 0.02 | 1 | 0.05 | 0.69 |
16p | 0.18 | 0 | 0.18 | 0.05 | <0.01 | 1 | 0.05 | 0.37 |
16q | 0.15 | 0.03 | 0.18 | 0.06 | 0.03 | 0.81 | 0.03 | 1 |
17p | 0.03 | 0.58 | 0.05 | 0.56 | 0.02 | 1 | −0.02 | 1 |
17q | 0.06 | 0.09 | 0.12 | 0.15 | 0.06 | 0.4 | 0.06 | 0.44 |
18p | 0.03 | 0.49 | 0.09 | 0.61 | 0.06 | 0.33 | 0.13 | 0.19 |
18q | 0 | 0.49 | 0.01 | 0.66 | 0.01 | 1 | 0.18 | 0.05 |
19p | 0.09 | 0.03 | 0.11 | 0.04 | 0.02 | 1 | 0.01 | 1 |
19q | 0.09 | 0 | 0.15 | 0.05 | 0.06 | 0.44 | 0.05 | 0.37 |
20p | 0.24 | 0.12 | 0.58 | 0.32 | 0.34 | 3 × 10 −4 | 0.20 | 0.02 |
20q | 0.36 | 0 | 0.72 | 0.15 | 0.36 | 1 × 10 −4 | 0.15 | 0.01 |
21q | 0.03 | 0.15 | 0.02 | 0.22 | −0.01 | 0.52 | 0.07 | 0.5 |
22q | 0 | 0.24 | 0.03 | 0.26 | 0.03 | 0.60 | 0.02 | 1 |
Mean | 0.086 | 0.126 | 0.167 | 0.17 | 0.081 | <0.0001 | 0.044 | <0.0001 |
1The fractional difference in chromosome arm gains, subtracting the frequency of arm gains in CCCC AA CRC cases from the frequency in TCGA NHW CRC cases. Gains in excess of 15% are shaded bold.
2 P values were calculated by Fisher exact test. Values in bold are significant after Bonferroni correction.
3The fractional difference in chromosome arm losses, subtracting the frequency of arm losses in CCCC AA CRC cases from the frequency in TCGA NHW CRC cases. Losses in excess of 15% are shaded bold.