Fig. 4.

An instance of simulated lesion data $R_{sim}$ (shown at slice $z=45$ and age bin number $t=20$). (a) Addition of random noise to μ indicating randomly sampled voxels, (b) lesion voxels after smoothing (a) with K, (c) $K\ast \mu$, (d) Sum of binary lesion maps ($R_{sim}$) in a specific age group, (e) Simulated ${\theta }_{true}$ image $N_{sim}$.