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. 2018 Nov 12;8(21):5890–5902. doi: 10.7150/thno.27667

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BPI-9016M inhibits DKK1 expression in lung adenocarcinoma cells. (A) Volcano plot depicting a log transformation plot of the fold difference (x-axis) and the p value (y-axis) of indicated genes between BPI-9016M-treated cells and control cells (vehicle treatment). (B) Signaling pathways were enriched in the BPI-9016M-treated A549 cells over the vehicle control by KEGG analysis using RNA sequencing. (C) FPKM values of nine genes associated with metastasis in the BPI-9016M-treated A549 cells by RNA sequencing analysis. ***P<0.0001. (D) The nine genes were investigated in the BPI-9016M-treated A549 cells by qPCR analysis. (E) Western blotting analysis shows the DKK1 expression level in BPI-9016M-treated A549 and H1299 cells. (F) Western blotting analysis shows the DKK1 expression level in cells treated with HGF and BPI-9016M alone or in combination.