Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 13;68(1):15–17. doi: 10.2337/dbi18-0045

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 by the American Diabetes Association.

Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. More information is available at http://www.diabetesjournals.org/content/license.

PMC Copyright notice

GLP-1 interactions with the brain. GLP-1–producing cells (yellow circles) are found in areas including the ileum, olfactory bulb, and hindbrain. GLP-1–responsive structures in the brain are far more distributed and include structures behind (blue) and outside of (red) the blood-brain barrier, a subset of which are represented in this schematic. Knowing which source of GLP-1 acts on which of the responsive structures is important in order to understand the role of endogenous GLP-1 in the control of the diverse effects of GLP-1; question marks highlight the lack of detail in current knowledge about the sources of GLP-1 to these and other GLP-1–responsive sites. The article by Holt et al. (7) offers an important step toward this understanding. AP, area postrema; Arc, arcuate hypothalamic nucleus; IO, inferior olive; IP, interpeduncular nucleus; LH, lateral hypothalamus; LS, lateral septum; OVLT, organum vasculosum of the lamina terminalis; PDTg, posterodorsal tegmental nucleus; PVN, paraventricular hypothalamic nucleus; SCN, suprachiasmatic nucleus; SFO, subfornical organ; SON, supraoptic nucleus; VTA, ventral tegmental area.