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Microbial Biotechnology logoLink to Microbial Biotechnology
. 2018 Dec 21;12(1):180–181. doi: 10.1111/1751-7915.13368

Antimicrobial peptides

An annotated selection of World Wide Web sites relevant to the topics in microbial biotechnology

Lawrence P Wackett 1
PMCID: PMC6302706  PMID: 30575296

Compendium of antimicrobial peptide databases

https://omictools.com/antimicrobial-peptide-data-category

This Omic tool listing contains an annotated set of antimicrobial databases. Antimicrobial peptides are increasingly deemed to be important in biotechnology for their animal and human therapeutic potential.

The anti‐microbial peptide database

http://aps.unmc.edu/AP/structure.php

This site contains a database of peptides, prediction tools and classification schema. Overall, it is a comprehensive resource on the topic.

Collection of anti‐microbial peptides

http://www.camp.bicnirrh.res.in

This collection focuses on sequence patterns and HMMs for antimicrobial peptides and provides links to major databases such as UniProt and PubMed.

Peptaibol database

http://www.cryst.bbk.ac.uk/peptaibol

This site focuses on a specific class of antimicrobial peptides known as peptaibols. These peptides are typically derived from fungi.

Database AMP

http://csb.cse.yzu.edu.tw/dbAMP/

This database is particularly useful for identifying antimicrobial peptides using transcriptomic and proteomic data.

Database of antimicrobial activity

https://dbaasp.org

This database specializes in modeling structures of antimicrobial peptides to help predict therapeutic potential for these compounds.

Tachystatin A structure

http://www.rcsb.org/structure/1CIX

This record in the Protein DataBank has information and structural coordinates for techystatin A, an antimicrobial peptide from horseshoe crab.

Four structural classes of antimicrobial peptides

https://www.researchgate.net/figure/Four-structural-classes-of-antimicrobial-peptides-A-a-helical-structure-of-human_fig1_281555477

This page from the Research Gate site posts information on a specific collection of antimicrobial peptides from animal origin.

Structure of anoplin in micelles

https://www.rcsb.org/structure/2MJQ

This record in the Protein DataBank has information and structural coordinates for antimicrobial peptide anoplin that is embedded in diphosphatidylcholine micelles. Anoplin is an antimicrobial peptide from a species of wasp.

Antimicrobial peptides review

https://www.mdpi.com/2218-273X/8/1/4/htm

This review article explores antimicrobial peptides, especially from the standpoint of providing a replacement of some antibiotic therapies where resistance is rising.

Antimicrobial peptides for wounds

https://www.frontiersin.org/articles/10.3389/fphar.2018.00281/full

This article discusses the use of antimicrobial peptides for surface injuries such as skin wounds.

General Probiotics

http://gprobiotics.com

General Protobiotics is a biotechnology company exploring commercial use of antimicrobial peptides in the poultry industry, as a replacement for antibiotics. The use of antibiotics in animal agriculture is increasingly being constrained.

Selling antimicrobial peptides: Hycult Biotech

https://www.hycultbiotech.com/products/innate/antimicrobialpeptides

This biotechnology company sells a variety of antimicrobial peptides, largely for research purposes.

Antimicrobial peptides: Gordon Research Conference

https://www.grc.org/antimicrobial-peptides-conference/2019/

This Gordon Research Conference is designed to host high‐level discussion of antimicrobial peptides, with a particular focus on their potential efficacy in human and veterinary medicine.

Designing antibacterial peptides

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829097/

An important area of antimicrobial peptide research is understanding structure/function correlations. This is discussed here in the context of designing more effective, faster‐acting peptides.

Molecular simulations of antimicrobial peptides

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2989729/

Antimicrobial peptides largely exert their effects in membranes. This study uses molecular dynamics simulations to better understand the interactions between the peptides and specific membrane components.

Antimicrobial peptides: Wikipedia

https://en.wikipedia.org/wiki/Antimicrobial_peptides

This Wikipedia entry provides a particularly good tutorial on many aspects of antimicrobial peptides.

Structure/function of antimicrobial peptides

https://www.sciencedirect.com/science/article/pii/S1876162318300282

This review focuses on biophysical and computational methods for studying antimicrobial peptides.

Microbial Biotechnology (2019) 12(1), 180–181


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