Table 2.
Male |
Female |
|||||
---|---|---|---|---|---|---|
Control | AdGHRKO | P Value | Control | AdGHRKO | P Value | |
NEFA | 0.81 ± 0.06 | 0.78 ± 0.04 | 0.747 | 0.78 ± 0.05 | 0.79 ± 0.04 | 0.846 |
Leptin | 6267 ± 1456 | 6845 ± 1538 | 0.789 | 2309 ± 310 | 2890 ± 690 | 0.417 |
Resistin | 11,341 ± 1174 | 6391 ± 418 | 0.002a | 15,149 ± 1752 | 8907 ± 911 | 0.014b |
Adiponectin | 21,530 ± 1216 | 14,150 ± 1544 | 0.001a | 34,403 ± 1647 | 24,801 ± 2317 | 0.005a |
MCP1 | 192 ± 64 | 122 ± 31 | 0.366 | 194 ± 43 | 106 ± 54 | 0.215 |
TNFa | 56 ± 21 | 26 ± 10 | 0.241 | 45 ± 15 | 25 ± 17 | 0.385 |
IL-6 | 125 ± 28 | 102 ± 16 | 0.493 | 111 ± 14 | 87 ± 43 | 0.562 |
FGF21 | 71 ± 26 | 29 ± 11 | 0.154 | 61 ± 18 | 41 ± 10 | 0.390 |
FSTL1 | 68 ± 0 | 191 ± 78 | 0.130 | 143 ± 56 | 96 ± 19 | 0.494 |
Myostatin | 297 ± 152 | 83 ± 34 | 0.186 | 160 ± 140 | 15 ± 1 | 0.392 |
OSTCRN | 42 ± 5 | 31 ± 4 | 0.100 | 54 ± 4 | 27 ± 3 | 6 × 10−5c |
SPARC | 19,240 ± 1997 | 17,970 ± 1748 | 0.639 | 17,493 ± 1056 | 20,918 ± 1999 | 0.130 |
Values are represented in pg/mL (or mmol/L for NEFA) as mean ± SEM (n = 6 to 11 per group). Measurements made at 6 mo of age.
Abbreviations: FGF21, fibroblast growth factor 21; FSTL1, follistatin-related protein 1; MCP1, monocyte chemoattractant protein 1; OSTCRN, osteocrin/musclin; SPARC, osteonectin; TNFa, TNF-α.
P < 0.01.
P < 0.05.
P < 0.001.