Table 3.
Phenotypic Comparison of GHRKO, FaGHRKO, and AdGHRKO Mouse Lines
| GHRKO | FaGHRKO | AdGHRKO | |
|---|---|---|---|
| GH | ↑ | ↔ | ↔ |
| IGF-1 | ↓ | ↑♂, ↔♀ | ↔ |
| Body length | ↓ | ↑ | ↔ |
| Percentage body fat | ↑ | ↑ | ↑ |
| Liver triglycerides | ↑ | ↔ | ↓ |
| Glucose homeostasis | |||
| Glucose | ↔↓ | ↔ | ↔ |
| Insulin/C-peptide | ↓ | ↔ | ↓ |
| Glucose tolerance | Impaired | ↔ | ↔ |
| Insulin sensitivity | Enhanced | ↔ | Enhanced |
| Adipokines | |||
| Leptin | ↔↑ | ↔♂, ↑♀ | ↔ |
| Resistin | ↑ | ↔ | ↓ |
| Adiponectin | ↑ | ↓♂, ↔♀ | ↓ |
| SC WAT | |||
| Depot weight | ↑ | ↑ | ↑ |
| Adipocyte size | ↑ | ↑ | ↑ |
| Fibrosis | nr | ↓ | ↓ |
| Perigonadal WAT | |||
| Depot weight | ↔ | ↔♂, ↑♀ | ↔♂, ↑♀ |
| Adipocyte size | ↔ | ↑ | ↔♂, ↑♀ |
| Fibrosis | nr | ↔ | ↔ |
| Lifespan | ↑ | ↓♂, ↔♀ | nr |
↑ indicates increased; ↓, decreased; ↔, unchanged; ↔↓, unchanged or decreased; and ↔↑ indicates unchanged or increased.
Abbreviation: nr, not reported in the literature.