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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: ChemMedChem. 2016 Mar 16;11(16):1709–1720. doi: 10.1002/cmdc.201600015

Table 2.

Effects of selected cHTC derivatives and reference compounds on the HIV-1 RT-associated RNA dependent DNA polymerase function.

Compd HIV-1 RDDP
IC50 [μM][a]
6 > 50
9 > 50
12 > 50
23 > 50
31 > 50
33 20.90 ± 1.70
34 > 50
36 > 50
1 > 50
3
efavirenz 		25.40 ± 3.70
0.023 ± 0.0016
[a]

IC50: compound concentration required to inhibit the HIV-1 RT-associated RNA dependent DNA polymerase activity by 50%. The table reports the average and standard deviation of three independent experiments, made in duplicate.