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. Author manuscript; available in PMC: 2018 Dec 28.
Published in final edited form as: Alcohol. 2017 Dec 6;72:19–31. doi: 10.1016/j.alcohol.2017.11.036

Figure 2.

Figure 2.

KLF12 results. A) LocusZoom plot of human KLF12 GWAS signal. B) Knockout of klf3, the C. elegans ortholog of KLF12, blocks the development of acute functional tolerance (AFT). C) Mouse basal Klf12 expression in prefrontal cortex (PFC) is significantly correlated with locomotor activity 0–5 minutes after 2.25 g/kg intraperitoneal ethanol. D) Mouse basal Klf12 expression in nucleus accumbens (Nac) is suggestively correlated with the development of acute functional tolerance (AFT).