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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Pain. 2019 Jan;160(1):117–135. doi: 10.1097/j.pain.0000000000001385

Figure 7. BA does not bind to the opioid receptors.

Figure 7.

Competition radioligand binding was performed in CHO cells expressing the human MOR, DOR, or KOR (see Methods for details). BA or a positive control compound was competed against 3H-diprenorphine in all 3 cell lines. Curves reported as the mean ± SEM of the mean value from each individual experiment in n = 3 independent experiments. The KI also reported as the mean ± SEM of the individual value from each of n = 3 independent experiments. BA did not produce competition binding up to 10 μM in any cell line. (A) MOR: Naloxone KI = 33.9 ± 1.7 nM. (B) DOR: Naloxone KI = 55.7 ± 6.7 nM. (C) KOR: U50,488 KI = 22.4 ± 4.1 nM.