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Effect of FRZB expression on leukemogenesis and β-catenin activity of Philadelphia-positive (Ph+) BV173 cells. (A) Survival of mice injected with 2×106 BV173-ShMYB 7TFP pUltra-Empty Vector (EV) or BV173-ShMYB 7TFP pUltra-hot-FRZB cells (FRZB). (B) Luciferase reporter assay for β-catenin activity in GFP+ cells isolated from the bone marrow (bm) or spleen (sp) of a NOD scid gamma (NSG) mouse injected with (EV)- or FRZB-BV173 cells and sacrificed when terminally ill.
