Table 2.
Relationship between the delay of NAC therapy and biological variables and complications. Legend: APAP × AT, paracetamol–aminotransferase product; CRRT, continuous renal replacement therapy.
| Variables (Median) | Time to NAC 12 h | Time to NAC 12–24 h | Time to NAC 24–48 h | Time to NAC >48 h | p-Value |
|---|---|---|---|---|---|
| (n = 32) | (n = 32) | (n = 8) | (n = 12) | ||
| Bilirubin max (mg/dL) | 8.5 | 4.7 | 5 | 6.3 | 0.86 |
| Peak AST (IU/L) | 13,255 | 10,150 | 11,975 | 10,176 | 0.47 |
| Peak ALT (IU/L) | 7520 | 699 | 10,075 | 7050 | 0.16 |
| APAP × AT (mg/L × IU/L) | 48,538 | 58,658 | 29,520 | 70,403 | 0.96 |
| Factor V min V (%) | 15 | 12 | 13 | 41 | 0.1 |
| Peak ammonia (µg/dL) | 227 | 185 | 225 | 202 | 0.9 |
| Arterial pH min | 7.36 | 7.37 | 7.4 | 7.35 | 0.44 |
| Lactate max (mmol/L) | 3.5 | 3.3 | 2 | 2.9 | 0.78 |
| Creatinine max (mg/dL) | 1.04 | 1.43 | 1.13 | 1.85 | 0.36 |
| Need for vasopressors | 11 (34%) | 8 (25%) | 1 (12%) | 0 | 0.1 |
| CRRT | 8 (25%) | 10 (31%) | 2 (25%) | 4 (33%) | 0.92 |
| Mechanical ventilation | 11 (34%) | 11 (34%) | 1 (12%) | 5 (41%) | 0.58 |
| Infection | 11 (34%) | 5 (15%) | 3 (37%) | 4 (33%) | 0.33 |
| Mortality | 6 (18%) | 3 (9%) | 0 | 0 | 0.2 |