Table 3.

Modification of the clinical scores¹ in the IBS patients in the different diets according to the challenge results.

Clinical Scores	Diet	Average Value ± SD	p Value
				Habitual Diet vs. Run-in Open Gluten-Free Diet	Run-in Open Gluten-Free Diet vs. Reduced-Gluten Diet	Run-in Open-Gluten-Free diet vs. Normal-Gluten Diet	Reduced-Gluten Diet vs. Normal-Gluten Diet
IBS-SS	Habitual diet	237.3 ± 70.25	IBS-SS	0.000	0.002	0.000	0.166
	Run-in Open gluten-free diet	164.8 ± 79.15
	Reduced-gluten diet	214.4 ± 97.59
	Normal-gluten diet	229.5 ± 79.82
VAS	Habitual diet	4.0 ± 1.54	VAS	0.000	0.000	0.000	0.042
	Run-in Open gluten-free diet	2.8 ± 1.40
	Reduced-gluten diet	3.7 ± 1.77
	Normal-gluten diet	4.3 ± 1.67
HADS	Habitual diet	22.9 ± 12.70	HADS	0.027	0.314	0.423	0.357
	Run-in Open gluten-free diet	20.3 ± 10.65
	Reduced-gluten diet	19.7 ± 10.82
	Normal-gluten diet	20.7 ± 12.35
QoL	Habitual diet	50.8 ± 27.94	QoL	0.000	0.000	0.046	0.357
	Run-in Open gluten-free diet	39.5 ± 24.92
	Reduced-gluten diet	45.2 ± 26.43
	Normal-gluten diet	47.3 ± 24.69

¹ IBS-SS, Irritable Bowel Syndrome Severity Score; VAS, Visual Analogue Scale; HADS, Hospital Anxiety and Depression Scale; QoL, Quality of Life.