Table 1.
Baseline characteristics by quartile of TNFR1 (N=985).
| Q1 (n=247) 0.21–1.86 ng/ml |
Q2 (n=246) 1.87–2.47 ng/ml |
Q3 (n=246) 2.48–3.40 ng/ml |
Q4 (n=246) 3.41–38.5 ng/ml |
p-valuea | |
|---|---|---|---|---|---|
| Demographic factors | |||||
| Age (years) | 62 (54, 69) | 66 (59, 73) | 69 (62, 76) | 73 (64, 79) | <0.001 |
| White race | 109 (44%) | 142 (58%) | 182 (74%) | 160 (65%) | <0.001 |
| Male | 186 (76%) | 200 (81%) | 213 (86%) | 203 (83%) | 0.024 |
| BMI (kg/m2) | 27.2 (24.4, 30.2) | 27.4 (24.7, 31.3) | 28.0 (25.3, 31.3) | 28.2 (24.9, 31.6) | 0.110 |
| Never smoker | 64 (26%) | 78 (32%) | 83 (34%) | 74 (30%) | 0.305 |
| Clinical history | |||||
| Hypertension | 162 (66%) | 168 (68%) | 165 (67%) | 197 (80%) | 0.002 |
| Diabetes mellitus | 44 (18%) | 62 (25%) | 66 (27%) | 86 (35%) | <0.001 |
| Myocardial infarction | 125 (51%) | 128 (52%) | 124 (51%) | 148 (61%) | 0.090 |
| Heart failure | 28 (11%) | 41 (17%) | 41 (17%) | 63 (26%) | <0.001 |
| COPD/Asthma | 38 (16%) | 39 (16%) | 39 (16%) | 40 (16%) | 0.997 |
| Medication use | |||||
| Aspirin | 187 (76%) | 190 (77%) | 199 (81%) | 186 (76%) | 0.545 |
| Statins | 148 (60%) | 165 (67%) | 160 (65%) | 159 (65%) | 0.443 |
| ACE inhibitor / ARB | 94 (38%) | 124 (50%) | 141 (57%) | 146 (59%) | <0.001 |
| Beta blocker | 127 (52%) | 140 (57%) | 143 (58%) | 156 (63%) | 0.071 |
| Metabolic markers | |||||
| HDL cholesterol (mg/dl) | 46 (37, 56) | 43 (37, 54) | 43 (36, 52) | 41 (34, 50) | 0.001 |
| LDL cholesterol (mg/dl) | 98 (85, 125) | 99 (84, 123) | 102 (82, 121) | 97 (79, 116) | 0.178 |
| C-reactive protein (mg/L) | 2.9 (1.3, 6.5) | 2.8 (1.4, 6.3) | 3.9 (1.8, 8.9) | 5.0 (2.2, 15.5) | <0.001 |
| Triglycerides (mg/dl) | 99 (68, 137) | 111 (73, 170) | 112 (75, 159) | 126 (78, 188) | 0.002 |
| Glycosylated hemoglobin (%) | 5.5 (5.1, 5.8) | 5.7 (5.3, 6.1) | 5.7 (5.4, 6.4) | 5.8 (5.5, 6.5) | <0.001 |
| Kidney function | |||||
| eGFR (ml/min/1.73 m2) | 89.2 (77.9, 99) | 78.3 (66.1, 87.3) | 67.3 (57.7, 76.8) | 47.3 (36.1, 59.2) | <0.001 |
| ACR (mg/g) | 7.1 (3.9, 12.7) | 8.1 (4.1, 15.0) | 8.8 (5.1, 17.5) | 14.3 (7.4, 67.8) | <0.001 |
| Cardiac function | |||||
| LV ejection fraction (%) | 65 (60, 69) | 64 (59, 68) | 63 (57, 68) | 63 (57, 67) | 0.017 |
| Treadmill exercise capacity (METs) | 8 (7, 10) | 8 (6, 10) | 7 (5, 10) | 5 (4, 7) | <0.001 |
Values reported as n (%), mean (SD), or median (IQR).
a
p-value is by χ2 test for categorical variables and Kruskal-Wallis test for continuous variables.
COPD: Chronic Obstructive Pulmonary Disease; ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker; HDL: high-density lipoprotein; LDL: low-density lipoprotein; eGFR: estimated glomerular filtration rate; LV: left ventricular; METs: Metabolic Equivalents.