Table 2. Genomic typing HLA alleles.
| Patient | Sample | HLA-A | HLA-B | HLA-C | HLA-DRB1 | HLA-DQB1 | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | #1 | A*03:01 | A*26:01 | B*07:02 | B*35:01 | C*03:03 | C*07:02 | DRB1*15:01 | DRB1*15:01 | DQB1*05:02 | DQB1*06:02 |
| #2 | A*03:01 | A*26:01 | B*07:02 | B*35:01 | C*03:03 | C*07:02 | DRB1*15:01 | DRB1*15:01 | DQB1*05:02 | DQB1*06:02 | |
| 2 | #1 | A*11:01 | A*31:01 | B*13:02 | B*51:01 | C*06:02 | C*15:02 | DRB1*07:01 | DRB1*08:01 | DQB1*02:02 | DQB1*04:02 |
| #2 | A*11:01 | A*31:01 | B*13:02 | B*51:01 | C*06:02 | C*15:02 | DRB1*07:01 | DRB1*08:01 | DQB1*02:02 | DQB1*04:02 | |
| 3 | #1 | A*24:02 | A*32:01 | B*40:06 | B*52:01 | C*12:02 | C*15:02 | DRB1*04:07 | DRB1*13:02 | DQB1*03:01 | DQB1*06:04 |
| #2 | A*24:02 | A*32:01 | B*40:06 | B*52:01 | C*12:02 | C*15:02 | DRB1*04:07 | DRB1*13:02 | DQB1*03:01 | DQB1*06:04 | |
| 4 | #1 | A*02:02 | A*13:01 | B*07:02 | B*15:16 | C*07:02 | C*14:02 | DRB1*01:03 | DRB1*07:01 | DQB1*02:02 | DQB1*05:01 |
| #2 | A*02:02 | A*13:01 | B*07:02 | B*15:16 | C*07:02 | C*14:02 | DRB1*01:03 | DRB1*07:01 | DQB1*02:02 | DQB1*05:01 | |
| 5 | #1 | A*02:01 | A*02:02 | B*44:02 | B*58:01 | C*05:01 | C*07:01 | DRB1*04:05 | DRB1*11:01 | DQB1*03:01 | DQB1*03:01 |
| #2 | A*02:01 | A*02:02 | B*44:02 | B*58:01 | C*05:01 | C*07:01 | DRB1*04:05 | DRB1*11:01 | DQB1*03:01 | DQB1*03:01 | |
| 6 | #1 | A*01:01 | A*24:02 | B*13:02 | B*44:02 | C*05:01 | C*06:02 | DRB1*03:01 | DRB1*04:08 | DQB1*02:01 | DQB1*03:01 |
| #2 | A*01:01 | A*24:02 | B*13:02 | B*44:02 | C*05:01 | C*06:02 | DRB1*03:01 | DRB1*04:08 | DQB1*02:01 | DQB1*03:01 | |
| 7 | #1 | A*01:01 | A*03:01 | B*35:08 | B*44:03 | C*04:01 | C*16:01 | DRB1*07:01 | DRB1*11:01 | DQB1*05:01 | DQB1*06:04 |
| #2 | A*01:01 | A*03:01 | B*35:08 | B*44:03 | C*04:01 | C*16:01 | DRB1*07:01 | DRB1*11:01 | DQB1*05:01 | DQB1*06:04 | |
| 8 | #1 | A*02:01 | A*02:01 | B*35:03 | B*44:03 | C*04:01 | C*04:01 | DRB1*07:01 | DRB1*07:01 | DQB1*02:02 | DQB1*02:02 |
| #2 | A*02:01 | A*02:01 | B*35:03 | B*44:03 | C*04:01 | C*04:01 | DRB1*07:01 | DRB1*07:01 | DQB1*02:02 | DQB1*02:02 | |
| 9 | #1 | A*30:02 | − | B*18:01 | − | C*05:01 | − | DRB1*03:01 | − | DQB1*02:01 | − |
| #2 | A*30:02 | A*66:01 | B*18:01 | B*51:01 | C*05:01 | C*07:01 | DRB1*03:01 | DRB1*13:03 | DQB1*02:01 | DQB1*03:01 | |
| 10 | #1 | A*02:01 | − | − | B*18:01 | C*07:01 | − | − | DRB1*11:04 | DQB1*03:01 | − |
| #2 | A*02:01 | A*02:01 | B*39:01 | B*18:01 | C*07:01 | C*12:03 | DRB1*11:01 | DRB1*11:04 | DQB1*03:01 | DQB1*03:01 | |
| 11 | #1 | A*03:01 | A*32:01 | B*15:01 | B*52:01 | C*03:03 | C*12:02 | DRB1*04:04 | DRB1*15:02 | DQB1*03:02 | DQB1*06:01 |
| #2 | A*03:01 | A*32:01 | B*15:01 | B*52:01 | C*03:03 | C*12:02 | DRB1*04:04 | DRB1*15:02 | DQB1*03:02 | DQB1*06:01 | |
| 12 | #1 | A*30:02 | A*33:01 | B*14:02 | B*40:01 | C*03:04 | C*08:02 | DRB1*04:04 | DRB1*13:03 | DQB1*03:01 | DQB1*03:02 |
| #2 | A*30:02 | A*33:01 | B*14:02 | B*40:01 | C*03:04 | C*08:02 | DRB1*04:04 | DRB1*13:03 | DQB1*03:01 | DQB1*03:02 | |
| 13 | #1 | A*01:01 | A*02:01 | B*18:01 | B*39:01 | C*05:01 | C*12:03 | DRB1*14:01 | DRB1*15:01 | DQB1*05:03 | DQB1*06:02 |
| #2 | A*01:01 | A*02:01 | B*18:01 | B*39:01 | C*05:01 | C*12:03 | DRB1*14:01 | DRB1*15:01 | DQB1*05:03 | DQB1*06:02 | |
| 14 | #1 | A*01:01 | A*31:01 | B*08:01 | B*53:01 | C*04:01 | C*07:01 | DRB1*01:01 | DRB1*03:01 | DQB1*02:01 | DQB1*05:01 |
| #2 | A*01:01 | A*32:01 | B*08:01 | B*53:01 | C*04:01 | C*07:01 | DRB1*01:01 | DRB1*03:01 | DQB1*02:01 | DQB1*05:01 | |
| 15 | #1 | A*25:01 | A*30:02 | B*18:01 | B*44:02 | C*05:01 | C*05:01 | DRB1*10:01 | DRB1*13:01 | DQB1*05:01 | DQB1*06:03 |
| #2 | A*25:01 | A*30:02 | B*18:01 | B*44:02 | C*05:01 | C*05:01 | DRB1*10:01 | DRB1*13:01 | DQB1*05:01 | DQB1*06:03 | |
| 16 | #1 | A*24:02 | A*30:02 | B*18:01 | B*50:01 | C*05:01 | C*06:02 | DRB1*03:01 | DRB1*04:04 | DQB1*02:01 | DQB1*04:02 |
| #2 | A*24:02 | A*30:02 | B*18:01 | B*50:01 | C*05:01 | C*06:02 | DRB1*03:01 | DRB1*04:04 | DQB1*02:01 | DQB1*04:02 | |
| 17 | #1 | A*02:01 | A*02:05 | B*18:01 | B*50:01 | C*05:01 | C*06:02 | DRB1*03:01 | DRB1*11:01 | DQB1*02:01 | DQB1*03:01 |
| #2 | A*02:01 | A*02:05 | B*18:01 | B*50:01 | C*05:01 | C*06:02 | DRB1*03:01 | DRB1*11:01 | DQB1*02:01 | DQB1*03:01 | |
| 18 | #1 | A*02:05 | A*31:01 | B*14:01 | B*58:01 | C*07:01 | C*08:02 | DRB1*03:01 | DRB1*04:05 | DQB1*02:01 | DQB1*03:02 |
| #2 | A*02:05 | A*31:01 | B*14:01 | B*58:01 | C*07:01 | C*08:02 | DRB1*03:01 | DRB1*04:05 | DQB1*02:01 | DQB1*03:02 | |
| 19 | #1 | A*29:02 | A*33:03 | B*44:02 | B*44:03 | C*05:01 | C*16:01 | DRB1*01:01 | DRB1*12:01 | DQB1*03:01 | DQB1*05:01 |
| #2 | A*29:02 | A*33:03 | B*44:02 | B*44:03 | C*05:01 | C*16:01 | DRB1*01:01 | DRB1*12:01 | DQB1*03:01 | DQB1*05:01 | |
| 20* | #1 | A*24:02 | A*29:02 | B*07:02 | B*44:03 | C*07:02 | C*16:01 | DRB1*07:01 | DRB1*15:01 | DQB1*02:02 | DQB1*06:02 |
| #2 | A*24:02 | A*29:02 | B*07:02 | B*44:03 | C*07:02 | C*16:01 | DRB1*07:01 | DRB1*15:01 | DQB1*02:02 | DQB1*06:02 | |
| 21* | #1 | A*01:01 | A*11:01 | B*35:02 | B*53:01 | C*04:01 | C*04:01 | DRB1*13:01 | DRB1*13:02 | DQB1*06:04 | DQB1*06:03 |
| #2 | A*01:01 | A*11:01 | B*35:02 | B*53:01 | C*04:01 | C*04:01 | DRB1*13:01 | DRB1*13:02 | DQB1*06:04 | DQB1*06:03 | |
| 22 | #1 | − | A*26:01 | − | B*38:01 | − | C*12:03 | DRB1*01:03 | − | DQB1*03:02 | − |
| #2 | A*02:01 | A*26:01 | B*07:02 | B*38:01 | C*07:02 | C*12:03 | DRB1*01:03 | DRB1*04:02 | DQB1*03:02 | DQB1*05:01 | |
| 23 | #1 | A*02:01 | A*66:01 | B*51:05 | B*41:02 | C*04:01 | C*17:01 | DRB1*04:03 | DRB1*04:04 | DQB1*03:01 | DQB1*06:03 |
| #2 | A*02:01 | A*66:01 | B*51:05 | B*41:02 | C*04:01 | C*17:01 | DRB1*04:03 | DRB1*04:04 | DQB1*03:01 | DQB1*06:03 | |
| 24 | #1 | A*11:01 | A*11:01 | B*27:05 | B*35:01 | C*01:02 | C*04:01 | DRB1*01:01 | DRB1*14:01 | DQB1*05:01 | DQB1*05:03 |
| #2 | A*11:01 | A*11:01 | B*27:05 | B*35:01 | C*01:02 | C*04:01 | DRB1*01:01 | DRB1*14:01 | DQB1*05:01 | DQB1*05:03 | |
| 25 | #1 | A*03:01 | A*31:01 | B*35:03 | B*38:01 | C*04:01 | C*12:03 | DRB1*13:01 | DRB1*16:01 | DQB1*05:02 | DQB1*06:03 |
| #2 | A*03:01 | A*31:01 | B*35:03 | B*38:01 | C*04:01 | C*12:03 | DRB1*13:01 | DRB1*16:01 | DQB1*05:02 | DQB1*06:03 | |
| 26 | #1 | A*24:02 | A*32:01 | B*35:03 | B*35:08 | C*04:01 | C*04:01 | DRB1*11:01 | DRB1*13:02 | DQB1*03:01 | DQB1*06:09 |
| #2 | A*24:02 | A*32:01 | B*35:03 | B*35:08 | C*04:01 | C*04:01 | DRB1*11:01 | DRB1*13:02 | DQB1*03:01 | DQB1*06:09 | |
| 27 | #1 | A*26:01 | A*66:01 | B*41:02 | B*44:03 | C*16:01 | C*17:01 | DRB1*03:01 | DRB1*07:01 | DQB1*02:01 | DQB1*02:02 |
| #2 | A*26:01 | A*66:01 | B*41:02 | B*44:03 | C*16:01 | C*17:01 | DRB1*03:01 | DRB1*07:01 | DQB1*02:01 | DQB1*02:02 | |
Note: HLA Luminex typing of CD34+ leukemic blasts (#1) and autologous CD3+ T-cells (#2) in samples from 27 patients in the study.
*Patients 20 and 21, DNA used in analysis was obtained from CD14+ monocytes (Sample #1).
− : Non-detected/assigned allele. Red boxes indicate the three patients in which HLA haplotype loss was detected.