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. 2018 Dec 13;10(4):272. doi: 10.3390/pharmaceutics10040272

Table 1.

General classification of the main bioceramics used in the tissue engineering field based on their biological performance.

Bioinert Strengths Limitations References
Alumina (Al2O3) High fracture toughness, strength, and fatigue resistance Not biodegradable [16]
Zirconia (ZrO2) Wear resistance Risk of catastrophic fracture [17]
Pyrolytic carbon Biological inert, biocompatibility, hemocompatibility Not biodegradable [18]
Silicon carbide (SiC) Excellent mechanical properties, biocompatibility Not biodegradable [15]
Bioactive Strengths Limitations References
Calcium phosphates: High biocompatibility, similarity to bone mineral phase Brittle, poor mechanical properties [19]
  Hydroxyapatite (HAp) Chemical composition and Ca/P ratio closer to bone than any other calcium phosphate Low solubility, slow degradation rate [19]
  Tricalcium phosphate (TCP) Crystalline forms of high solubility, resorbability Low mechanical resistance, excessive resorbability [20]
  Biphasic calcium phosphates (BCP) Improved bone growth over HAp and TCP alone Hard to couple material degradation with tissue growth [21]
Bioactive glasses Strong bond to surrounding tissue, antibacterial properties Poor mechanical properties [22,23,24]
Coralline Excellent porous structure, interconnectivity High variability dependent on the source material [19]