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Molecular docking showing the overlay of donepezil (green) and compound 8l (navy blue) with the known BACE1 inhibitor (gray) crystallized with BACE1 (PDB# 4FM7 [25]), shown as ribbons. Panel A shows the three compounds in the active site of BACE1. Panels B–D show the zoomed-in view of the known inhibitor (B), donepezil (C), and compound 8l (D).
