Table 2.
Inhibition constants of anionic inhibitors against the α-CA isoforms hCA II and hCA I, as well as the β-class protozoan enzyme EhiCA, for the CO2 hydration reaction at 20 °C [31].
| Inhibitor § | KI [mM] # | ||
|---|---|---|---|
| hCA II | hCA I | EhiCA | |
| F− | >300 | >300 | >100 |
| Cl− | 200 | 6.0 | >100 |
| Br− | 63 | 4.1 | 36.8 |
| I− | 26 | 0.3 | 7.4 |
| CNO− | 0.03 | 0.0007 | 0.77 |
| SCN− | 1.6 | 0.2 | 7.9 |
| CN− | 0.02 | 0.0005 | >100 |
| N3− | 1.51 | 0.0012 | >100 |
| HCO3− | 85 | 12 | 0.28 |
| CO32− | 73 | 15 | 2.4 |
| NO3− | 35 | 7.0 | 3.6 |
| NO2− | 63 | 8.4 | 1.7 |
| HS− | 0.04 | 0.0006 | 6.9 |
| HSO3− | 89 | 18 | 11.5 |
| SO42− | >200 | 63 | 21.6 |
| SnO32− | 0.83 | 0.57 | 0.51 |
| SeO42− | 112 | 118 | 6.0 |
| TeO42− | 0.92 | 0.66 | 0.61 |
| P2O74− | 48.50 | 25.8 | >100 |
| V2O74− | 0.57 | 0.54 | >100 |
| B4O72− | 0.95 | 0.64 | 0.29 |
| ReO4− | 0.75 | 0.11 | 7.1 |
| RuO4− | 0.69 | 0.10 | 7.0 |
| S2O82− | 0.084 | 0.11 | 8.4 |
| SeCN− | 0.086 | 0.085 | 0.87 |
| CS32− | 0.0088 | 0.0087 | 6.0 |
| Et2NCS2− | 3.1 | 0.00079 | 0.51 |
| ClO4− | >200 | >200 | >100 |
| BF4− | >200 | >200 | >100 |
| FSO3− | 0.46 | 0.79 | 0.086 |
| PF6− | >200 | >200 | >100 |
| CF3SO3− | >200 | >200 | >100 |
| NH(SO3)22− | 0.76 | 0.31 | 2.2 |
| H2NSO2NH2 | 1.13 | 0.31 | 0.028 |
| H2NSO3H | 0.39 | 0.021 | >100 |
| Ph-B(OH)2 | 23.1 | 38.6 | 0.047 |
| Ph-AsO3H2 | 49.2 | 31.7 | 0.038 |
§ As sodium salt; # Errors were in the range of 3–5% of the reported values, from three different assays.