VOLUME 290 (2015) PAGES 30975–30987
This article has been withdrawn by Isha Kapoor, Kainat Khan, Gatha Thacker, Mohd. Parvez Khan, Nidhi Shukla, Jitendra Kumar Kanaujiya, Sabyasachi Sanyal, Naibedya Chattopadhyay, and Arun Kumar Trivedi. Yogesh Kumar could not be reached. The corresponding author identified some issues and brought them to the attention of the Journal. Subsequently, some issues were also noted in the article by the Journal. Based on the original data provided for Fig. 2C, the human Runx2 construct resolves at the size of β-actin. While they grossly differ in size (size of Runx2 is ∼60 kDa while that of β-actin is 42 kDa), the withdrawing authors claim that the loading control was possibly probed with β-tubulin (∼55 kDa), which separates at an almost similar size as Runx2 and was erroneously labeled as β-actin. The Runx2 immunoblots from Figs. 2E and 2J were duplicated, and the FLAG Fbw7 immunoblot from Fig. 2J was inappropriately manipulated. Additionally, the actin immunoblots from Figs. 3B and 3C were duplicated, the graphs shown in Figs. 4A and 4B were duplicated, and a non-matching image due to overcropping was used in the Fbw7 panel for the Ovx + E2 group in Fig. 6A, which the withdrawing authors state were inadvertent errors. Given these errors, the withdrawing authors state that the responsible course of action would be to withdraw the article to maintain the high standards and rigor of scientific literature from the withdrawing authors' group as well as the Journal. However, the withdrawing authors state that these errors do not change the underlying scientific findings of the article.