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. 2019 Jan 10;10:122. doi: 10.1038/s41467-018-07985-2

Iron-catalyzed carboazidation of alkenes and alkynes

Haigen Xiong 1,2, Nagarajan Ramkumar 1, Mong-Feng Chiou 1, Wujun Jian 1, Yajun Li 1, Ji-Hu Su 3, Xinhao Zhang 4, Hongli Bao 1,2,✉
PMCID: PMC6328574  PMID: 30631054

Abstract

Carboazidation of alkenes and alkynes holds the promise to construct valuable molecules directly from chemical feedstock therefore is significantly important. Although a few examples have been developed, there are still some unsolved problems and lack of universal methods for carboazidation of both alkenes and alkynes. Here we describe an iron-catalyzed rapid carboazidation of alkenes and alkynes, enabled by the oxidative radical relay precursor t-butyl perbenzoate. This strategy enjoys success with a broad scope of alkenes under mild conditions, and it can also work with aryl alkynes which are challenging substrates for carboazidation. A large number of diverse structures, including many kinds of amino acid precursors, fluoroalkylated vinyl azides, other specific organoazides, and 2H-azirines can be easily produced.

Carboazidation of alkenes and alkynes holds the promise to construct valuable, functionalized molecules. Here, the authors report a general and efficient iron-catalyzed carboazidation of both alkenes and alkynes enabled by t-butyl perbenzoate.

Introduction

Amino acids, the basic building blocks of proteins are being used increasingly in bio-relevant modification of proteins and pharmaceutical applications. Development of more versatile methods to provide useful but synthetically challenging amino acid frameworks from chemical feedstocks is always highly desired1–4. Carboazidation of alkenes and alkynes holds the promise to construct valuable molecules including amino acid precursors and has therefore attracted much attention recently. Although several carboazidations of alkenes have been developed by Huang5, Renaud6,7, Liu8, Masson9, Zhu10, Jiao11 and Xu12, there are some unsolved problems in this field. How to realize the carboazidation reaction using nontoxic, inexpensive and readily available reagents with a broad scope of olefins remains a question. In addition, the carboazidation of alkynes is even more challenging than carboazidation of alkenes (Fig. 1a). There is only one successful carboazidation of alkynes reported by Liu13 which works for single carbon functionality, i.e., a trifluoromethyl group using Togni’s reagent (Fig. 1b). The reason for the lack of methods for carboazidation of alkynes might be attributed to the relative lower efficiency of incorporation of azido species compared to other competing reactions. The development of carboazidation of alkenes and alkynes is significantly important from the synthetic point of view.

Fig. 1.

Fig. 1

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Carboazidation of alkenes and alkynes. a Previous arts on carboazidation of alkenes. b Previous arts on carboazidation of alkynes. c This work: carboazidation of alkenes and alkynes

t-Butyl perbenzoate (TBPB) is a commercially available and inexpensive oxidant frequently used as a precursor of the t-butoxyl radical14–22. Lately, TBPB has been proved to be a good source of methyl radical by Yu23 and our group4,24,25. Although our understanding of the selective formation of methyl radicals is limited, we found previously that in the presence of Fe(OTf)2 or Fe(OTf)3, the methyl radical is formed exclusively. We envisioned that TBPB could serve as a polyfunctional reagent for the carboazidation of alkenes and alkynes. Herein, we report our development of a versatile iron-catalyzed rapid carboazidation of both alkenes and alkynes, enabled by TBPB (Fig. 1c).

Results

Carboazidation of alkenes

We investigated the reaction parameters for carboazidation in the presence of TBPB and found that ferrous trifluoromethanesulfonate (Fe(OTf)2, ferrous triflate) is optimal (Fig. 2, see details in Supplementary Table 1 and Supplementary Figures 2–4), delivering the corresponding product 3 in 89% yield at rt with DME (dimethoxyethane) as the solvent and azidotrimethylsilane (TMSN3) as the azidation reagent. Possible by-products 4, 4′, and 4″ were not observed.

Fig. 2.

Fig. 2

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Optimized conditions for carboazidation of alkenes. Fe(OTf)2 (5 mol%), 1a (0.5 mmol), 2a (1.0 mmol), TMSN3 (1.0 mmol), TBPB (1.0 mmol) in DME (2 mL) at rt for 3 min under an N2 atmosphere

With the optimized conditions in hand, we studied the scope of the reaction with alkyl iodides (Fig. 3 and Supplementary Figures 5–34). Fluoroalkyl iodides were examined first and the corresponding fluoroalkyl-azidation products (5–10) were obtained in high yields26. The reaction of styrene with iodoacetonitrile proceeds smoothly, affording the corresponding product (11) in 86% yield. Reactions with ethyl iodoacetates affords products (12–14) with the yield ranging from 71–85%. With 1-iodo-3,3-dimethylbutan-2-one the reaction delivers the azide (15) in 61% yield. Three electron rich alkyl iodides, i.e., 1-chloro-4-iodobutane, 1-iododecane and 2-iodobutane are not effective in this reaction as the direct azidation of alkyl iodides to form alkyl azides occurs. It should be noted that the reactions with perfluoroalkyl iodides are very fast, completing in 10 min in many cases.

Fig. 3.

Fig. 3

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Scope of alkyl iodides. General reaction conditions: Fe(OTf)2 (3–5 mol%), 1a or 1b (0.5 mmol), 2 (0.65–1.0 mmol), TMSN3 (0.7–1.0 mmol), TBPB (0.75–1.0 mmol) in DME (2 mL) at rt under an N2 atmosphere. a Instead of TBPB, lauroyl peroxides (LPO, 0.75 mmol) was applied. b 50 °C

Subsequently, we studied the substrate scope of olefins (Fig. 4 and Supplementary Figs. 35–189). As examples, α-azido esters (16–27 in Fig. 4a), β-azido esters (28–37 in Fig. 4b), γ-azido esters (38–63 in Fig. 4c), other azido acid derivatives (64–69 in Fig. 4d–g) and organoazides (70–75 in Fig. 4h) were obtained. The functional group compatibility of this reaction is good: a series of functional groups, such as halogen, ester, carboxylic acid (69), and free hydroxyl group (74) are tolerated under the reaction conditions. Both terminal and internal alkenes (28–37, 58, and 65) are compatible with the reaction. The carboazidation reactions of 1-octene with iodomethane and iodobutane are not successful under the reaction conditions.

Fig. 4.

Fig. 4

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Scope of alkenes. a Synthesis of α-azido esters. b Synthesis of β-azido esters. c Synthesis of γ-azido esters. d Synthesis of α,γ-azido esters. e Synthesis of an α,β-azido ester. f Synthesis of an α,β,γ-azido ester. g Synthesis of an azido acid. h Synthesis of other organoazides. General reaction conditions: Fe(OTf)2 (5 mol%), 1 (0.5 mmol), 2 (0.65–1.0 mmol), TMSN3 (1.0 mmol), TBPB (1.0 mmol) in DME (2 mL) at rt under an N2 atmosphere. Isolated yields. dr values were determined by 1H NMR

To highlight the synthetic applications, 8, 19 and 78 were reduced to amine 7611, amino acid 7726 and pyrrolidinone 79, respectively (Fig. 5 and Supplementary Figs. 190–199).

Fig. 5.

Fig. 5

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Applications of carboazidation products. a Reduction to amine. b Reduction to α-amino acid. c Cyclization to pyrrolidinones

Carboazidation of alkynes

Vinyl azides (1-azidoalkenes)27,28 are versatile building blocks in organic synthesis and have been used in many transformations to synthesize bioactive alkaloids and heterocycles29–36. Although the carboazidation of alkynes can difunctionalize alkynes, affording 1-azidoalkenes which can be subsequently converted to 2H-azirines, reports of such efficient methods are rare13, and accordingly, we studied the carboazidation of alkynes. After carefully screening the reaction conditions, Fe(OTf)3 was found to be the best catalyst, producing a carboazidation product (81) while avoiding the formation of the atom-transfer radical addition (ATRA) product (81′) (Fig. 6a, see details in Supplementary Table 2 and Supplementary Figs. 200–208). In view of the broad synthetic utilities of 2H-azirines, the conversion of vinyl azides to 2H-azirines was studied. It was found that compound 81 could be converted into a 2H-azirine (82) in toluene at 120 °C (Fig. 6b).

Fig. 6.

Fig. 6

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Carboazidation of alkynes. a Optimized reaction conditions. b Cascade transformation of vinyl azide to 2H-azirine

With these conditions identified, we studied the substrate scope regarding alkyl iodides and alkynes. The results are shown in Fig. 7 and Supplementary Figs. 209–283. Fluoroalkyl iodides and aryl alkynes react well in these transformations. Reaction of 1-iododecane with ethynylbenzene does not deliver the desired product. As an example, reaction of 1-octyne delivers only the ATRA product (107)37 in 42% yield.

Fig. 7.

Fig. 7

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Substrate scope of carboazidation of alkynes and further transformation to 2H-azirines. General reaction conditions: Fe(OTf)3 (0.025 mmol), alkyne (0.5 mmol), RI (0.75 mmol), TMSN3 (1.0 mmol), TBPB (1.0 mmol) in DME (2 mL) at rt for 5–20 min and then in toluene at 120 °C for 10 min under an N2 atmosphere. Isolated yields

To highlight the synthetic applications of this method further, vinyl azides and 2H-azirine were converted to 10838 10939 and 11040 in high yields (Fig. 8 and Supplementary Figs. 284–295). The geometry of vinyl azides was confirmed by X-ray crystallographic analysis of product 109 (see details in Supplementary Figure 1 and Supplementary Table 3).

Fig. 8.

Fig. 8

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Further synthetic transformations. a Synthesis of 1,2,3-triazoles. b Synthesis of aziridine

Discussion

In summary, we have developed a carboazidation of alkenes and alkynes enabled by TBPB. This key transformation has been successfully used to afford various valuable structural skeletons, including many amino acid precursors, vinyl azides and 2H-azirines. It is noteworthy that this carboazidation works for both alkenes and alkynes with multiple carbon functionalities.

Methods

Typical procedure for carboazidation of alkenes

Fe(OTf)2 (9 mg, 0.025 mmol) was added to a dried Schlenk tube equipped with a magnetic bar. This tube was then flushed with N2 gas (3 times) and an N2 atmosphere was maintained using an N2 balloon. A thoroughly mixed solution of alkene (0.5 mmol), alkyl iodide (0.65–1.5 mmol), TMSN3 (0.7–1.7 mmol) and TBPB (0.75–1.75 mmol) in DME (2 mL) was added to the catalyst by syringe and the mixture was stirred vigorously for 3–120 min at the appropriate temperature. After completion of the reaction, judged by TLC, the solvent was evaporated and the residue was purified by flash chromatography on silica gel using petroleum ether and EtOAc to give the corresponding product.

Typical procedure for carboazidation of alkynes

Fe(OTf)3 (12.7 mg, 0.025 mmol) was added to a dried Schlenk tube equipped with a magnetic bar. Then this tube was flushed with N2 (3 times) and an N2 atmosphere was maintained using an N2 balloon. A thoroughly mixed solution of alkyne (0.5 mmol), RfI (0.75 mmol), TMSN3 (1.0 mmol) and TBPB (1.0 mmol) in DME (2 mL) was added to the catalyst by syringe and the mixture was stirred vigorously for 5–20 min at rt. After completion of the reaction, judged by TLC, the volatile compounds were removed by pump and the residue was dissolved in toluene (3 mL). The resulting mixture was then stirred at 120 °C for 10 min. The solvent was then evaporated and the residue was purified by flash chromatography on silica gel using petroleum ether and EtOAc to give the corresponding product.

Supplementary information

Supplementary Information (8.8MB, pdf)

Acknowledgements

We thank the National Key R&D Program of China (Grant No. 2017YFA0700103 and 2018YFA0306600), the NSFC (Grant Nos. 21502191, 21672213, 21871258), the Strategic Priority Research Program of the Chinese Academy of Sciences (Grant No. XDB20000000), the Haixi Institute of CAS (Grant No. CXZX-2017-P01) for financial support. We also thank Professors Daqiang Yuan, Weiping Su, and Tianlu Sheng from our institute for their suggestions.

Author contributions

H.X., N.R., and W.J. performed the synthetic experiments and analyzed the experimental data. H.B. directed the investigations and prepared the manuscript. H.X., M.-F.C., X.Z., J.-H.S., and Y.L. contributed to the discussion and preparation of the manuscript.

Data availability

Detailed experimental procedures and characterization of compounds can be found in the Supplementary Information. The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Centre (109: CCDC 1864994). These data could be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif. All data are available from the authors upon request.

Competing interests

The authors declare no competing interests.

Footnotes

Journal peer review information: Nature Communications thanks the anonymous reviewers for their contribution to the peer review of this work.

Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Supplementary Information accompanies this paper at 10.1038/s41467-018-07985-2.

References

  • 1.Cheng J, Qi X, Li M, Chen P, Liu G. Palladium-catalyzed intermolecular aminocarbonylation of alkenes: efficient access of beta-amino acid derivatives. J. Am. Chem. Soc. 2015;137:2480–2483. doi: 10.1021/jacs.5b00719. [DOI] [PubMed] [Google Scholar]
  • 2.Piou T, Rovis T. Rhodium-catalysed syn-carboamination of alkenes via a transient directing group. Nature. 2015;527:86–90. doi: 10.1038/nature15691. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Lerchen A, Knecht T, Daniliuc CG, Glorius F. Unnatural amino acid synthesis enabled by the Regioselective Cobalt(III)-catalyzed intermolecular carboamination of alkenes. Angew. Chem. Int. Ed. 2016;55:15166–15170. doi: 10.1002/anie.201608729. [DOI] [PubMed] [Google Scholar]
  • 4.Qian B, Chen S, Wang T, Zhang X, Bao H. Iron-catalyzed carboamination of olefins: synthesis of amines and disubstituted beta-amino acids. J. Am. Chem. Soc. 2017;139:13076–13082. doi: 10.1021/jacs.7b06590. [DOI] [PubMed] [Google Scholar]
  • 5.Huang WY, Lü L. The reaction of perfluoroalkanesulfinates VII. Fenton reagent-initiated addition of sodium perfluoroalkanesulfinates to alkenes. Chin. J. Chem. 1992;10:365–372. doi: 10.1002/cjoc.19920100413. [DOI] [Google Scholar]
  • 6.Renaud P, Ollivier C, Panchaud P. Radical carboazidation of alkenes: an efficient tool for the preparation of pyrrolidinone derivatives. Angew. Chem. Int. Ed. 2002;41:3460–3462. doi: 10.1002/1521-3773(20020916)41:18<3460::AID-ANIE3460>3.0.CO;2-6. [DOI] [PubMed] [Google Scholar]
  • 7.Weidner K, Giroult A, Panchaud P, Renaud P. Efficient carboazidation of alkenes using a radical desulfonylative azide transfer process. J. Am. Chem. Soc. 2010;132:17511–17515. doi: 10.1021/ja1068036. [DOI] [PubMed] [Google Scholar]
  • 8.Wang F, Qi X, Liang Z, Chen P, Liu G. Copper-catalyzed intermolecular trifluoromethylazidation of alkenes: convenient access to CF3-containing alkyl azides. Angew. Chem. Int. Ed. 2014;53:1881–1886. doi: 10.1002/anie.201309991. [DOI] [PubMed] [Google Scholar]
  • 9.Dagousset G, Carboni A, Magnier E, Masson G. Photoredox-induced three-component azido- and aminotrifluoromethylation of alkenes. Org. Lett. 2014;16:4340–4343. doi: 10.1021/ol5021477. [DOI] [PubMed] [Google Scholar]
  • 10.Bunescu A, Ha TM, Wang Q, Zhu J. Copper-catalyzed three-component carboazidation of alkenes with acetonitrile and sodium azide. Angew. Chem. Int. Ed. 2017;56:10555–10558. doi: 10.1002/anie.201705353. [DOI] [PubMed] [Google Scholar]
  • 11.Geng X, Lin F, Wang X, Jiao N. Azidofluoroalkylation of alkenes with simple fluoroalkyl iodides enabled by photoredox catalysis. Org. Lett. 2017;19:4738–4741. doi: 10.1021/acs.orglett.7b02056. [DOI] [PubMed] [Google Scholar]
  • 12.Zhu CL, et al. Iron(II)-Catalyzed Azidotrifluoromethylation of Olefins and N-heterocycles for expedient vicinal trifluoromethyl amine synthesis. ACS Catal. 2018;8:5032–5037. doi: 10.1021/acscatal.8b01253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 13.Wang F, Zhu N, Chen P, Ye J, Liu G. Copper-catalyzed trifluoromethylazidation of alkynes: efficient access to CF3-substituted azirines and aziridines. Angew. Chem. Int. Ed. 2015;54:9356–9360. doi: 10.1002/anie.201503412. [DOI] [PubMed] [Google Scholar]
  • 14.Tang S, et al. Iodine-catalyzed radical oxidative annulation for the construction of dihydrofurans and indolizines. Org. Lett. 2015;17:2404–2407. doi: 10.1021/acs.orglett.5b00912. [DOI] [PubMed] [Google Scholar]
  • 15.Kochi JK, Mains HE. Studies on the mechanism of the reaction of peroxides and alkenes with copper salts. J. Org. Chem. 1965;30:1862–1872. doi: 10.1021/jo01017a036. [DOI] [Google Scholar]
  • 16.Pryor WA, Hendrickson WH. Reaction of nucleophiles with electron acceptors by SN2 or electron transfer (ET) mechanisms: tert-butyl peroxybenzoate/dimethyl sulfide and benzoyl peroxide/N,N-dimethylaniline systems. J. Am. Chem. Soc. 1983;105:7114–7122. doi: 10.1021/ja00362a016. [DOI] [Google Scholar]
  • 17.Sekar G, Dattagupta A, Singh VK. Asymmetric Kharasch Reaction: Catalytic Enantioselective Allylic Oxidation of Olefins Using Chiral Pyridine Bis(diphenyloxazoline)−Copper Complexes andtert-Butyl Perbenzoate. J. Org. Chem. 1998;63:2961–2967. doi: 10.1021/jo972132p. [DOI] [Google Scholar]
  • 18.Kharasch MS, Sosnovsky G. The reactions of t-Butyl perbenzoate and olefins—a stereospecific reaction. J. Am. Chem. Soc. 1958;80:756–756. doi: 10.1021/ja01536a062. [DOI] [Google Scholar]
  • 19.Cai ZJ, et al. I2/TBPB mediated oxidative reaction of N-tosylhydrazones with anilines: practical construction of 1,4-disubstituted 1,2,3-triazoles under metal-free and azide-free conditions. Org. Lett. 2014;16:5108–5111. doi: 10.1021/ol502431b. [DOI] [PubMed] [Google Scholar]
  • 20.Chen W, Zhang Y, Li P, Wang L. tert-Butyl peroxybenzoate mediated formation of 3-alkylated quinolines from N-propargylamines via a cascade radical addition/cyclization reaction. Org. Chem. Front. 2018;5:855–859. doi: 10.1039/C7QO01052D. [DOI] [Google Scholar]
  • 21.Yu H, Li Z, Bolm C. Nondirected copper-catalyzed sulfoxidations of benzylic C-H bonds. Org. Lett. 2018;20:2076–2079. doi: 10.1021/acs.orglett.8b00615. [DOI] [PubMed] [Google Scholar]
  • 22.Shen SJ, Zhu CL, Lu DF, Xu H. Iron-catalyzed direct olefin diazidation via peroxyester activation promoted by nitrogen-based ligands. ACS Catal. 2018;8:4473–4482. doi: 10.1021/acscatal.8b00821. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 23.Guo S, Wang Q, Jiang Y, Yu J. T. tert-Butyl peroxybenzoate-promoted alpha-methylation of 1,3-dicarbonyl compounds. J. Org. Chem. 2014;79:11285–11289. doi: 10.1021/jo502204a. [DOI] [PubMed] [Google Scholar]
  • 24.Zhu N, Zhao J, Bao H. Iron catalyzed methylation and ethylation of vinyl arenes. Chem. Sci. 2017;8:2081–2085. doi: 10.1039/C6SC04274K. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 25.Jian W, Ge L, Jiao Y, Qian B, Bao H. Iron-catalyzed decarboxylative alkyl etherification of vinylarenes with aliphatic acids as the alkyl source. Angew. Chem. Int. Ed. 2017;56:3650–3654. doi: 10.1002/anie.201612365. [DOI] [PubMed] [Google Scholar]
  • 26.Green JE, Bender DM, Jackson S, O’donnell MJ, Mccarthy JR. Mitsunobu approach to the synthesis of optically active alpha,alpha-disubstituted amino acids. Org. Lett. 2009;11:807–810. doi: 10.1021/ol802325h. [DOI] [PubMed] [Google Scholar]
  • 27.Chiba S. Application of organic azides for the synthesis of nitrogen-containing molecules. Synlett. 2011;2012:21–44. doi: 10.1055/s-0031-1290108. [DOI] [Google Scholar]
  • 28.Jung N, Brase S. Vinyl and alkynyl azides: well-known intermediates in the focus of modern synthetic methods. Angew. Chem. Int. Ed. 2012;51:12169–12171. doi: 10.1002/anie.201206409. [DOI] [PubMed] [Google Scholar]
  • 29.Wang YF, Chiba S. Mn(III)-mediated reactions of cyclopropanols with vinyl azides: synthesis of pyridine and 2-azabicyclo[3.3.1]non-2-en-1-ol derivatives. J. Am. Chem. Soc. 2009;131:12570–12572. doi: 10.1021/ja905110c. [DOI] [PubMed] [Google Scholar]
  • 30.Wang YF, Toh KK, Lee JY, Chiba S. Synthesis of isoquinolines from alpha-aryl vinyl azides and internal alkynes by Rh-Cu bimetallic cooperation. Angew. Chem. Int. Ed. 2011;50:5927–5931. doi: 10.1002/anie.201101009. [DOI] [PubMed] [Google Scholar]
  • 31.Chen F, Shen T, Cui Y, Jiao N. 2,4- vs 3,4-disubsituted pyrrole synthesis switched by copper and nickel catalysts. Org. Lett. 2012;14:4926–4929. doi: 10.1021/ol302270z. [DOI] [PubMed] [Google Scholar]
  • 32.Chiba S, Wang YF, Lapointe G, Narasaka K. Synthesis of polysubstituted N-H pyrroles from vinyl azides and 1,3-dicarbonyl compounds. Org. Lett. 2008;10:313–316. doi: 10.1021/ol702727j. [DOI] [PubMed] [Google Scholar]
  • 33.Li X, Liao S, Wang Z, Zhang L. Ligand-accelerated gold-catalyzed addition of in situ generated hydrazoic acid to alkynes under neat conditions. Org. Lett. 2017;19:3687–3690. doi: 10.1021/acs.orglett.7b01359. [DOI] [PubMed] [Google Scholar]
  • 34.Forster MO, Newman SH. CCLXIII.—The triazo-group. Part XV. Triazoethylene (vinylazoimide) and the triazoethyl halides. J. Chem. Soc. Trans. 1910;97:2570–2579. doi: 10.1039/CT9109702570. [DOI] [Google Scholar]
  • 35.Liu Z, Liao P, Bi X. General silver-catalyzed hydroazidation of terminal alkynes by combining TMS-N3 and H2O: synthesis of vinyl azides. Org. Lett. 2014;16:3668–3671. doi: 10.1021/ol501661k. [DOI] [PubMed] [Google Scholar]
  • 36.Hassner, A. & Fowler, F. W. A. General synthesis of vinyl azides from olefins. Stereochemistry of elimination from beta-Iodo azides. J. Org. Chem.33, 2686–2691 (1968).
  • 37.Xu T, Cheung CW, Hu X. Iron-catalyzed 1,2-addition of perfluoroalkyl iodides to alkynes and alkenes. Angew. Chem. Int. Ed. 2014;53:4910–4914. doi: 10.1002/anie.201402511. [DOI] [PubMed] [Google Scholar]
  • 38.Ng EPJ, Wang YF, Hui BWQ, Lapointe G, Chiba S. Orthogonal synthesis of pyrroles and 1,2,3-triazoles from vinyl azides and 1,3-dicarbonyl compounds. Tetrahedron. 2011;67:7728–7737. doi: 10.1016/j.tet.2011.08.006. [DOI] [Google Scholar]
  • 39.Liu Z, et al. Silver(I)-catalyzed hydroazidation of ethynyl carbinols: synthesis of 2-azidoallyl alcohols. Angew. Chem. Int. Ed. 2014;53:5305–5309. doi: 10.1002/anie.201310264. [DOI] [PubMed] [Google Scholar]
  • 40.Hirashita T, Toumatsu S, Imagawa Y, Araki S, Setsune JI. Stereoselective allylation of azirines with allylindium reagents. Tetrahedron Lett. 2006;47:1613–1616. doi: 10.1016/j.tetlet.2005.12.119. [DOI] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

Supplementary Information (8.8MB, pdf)

Data Availability Statement

Detailed experimental procedures and characterization of compounds can be found in the Supplementary Information. The X-ray crystallographic coordinates for structures reported in this article have been deposited at the Cambridge Crystallographic Data Centre (109: CCDC 1864994). These data could be obtained free of charge from The Cambridge Crystallographic Data Centre via www.ccdc.cam.ac.uk/data_request/cif. All data are available from the authors upon request.

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