Table 2.
Epoxycarvone stereoisomers effect on maximal electroshock-induced seizures test (MES).
| Experimental Groups | Seizures Duration (s) | Tonic Seizures (%) | Mortality (%) |
|---|---|---|---|
| Control (Tween 80 5%) | 16.3 ± 0.9 | 100 | 37.5 |
| Phenytoin (standard) | 0.0 ± 0.0 a | 0 | 0 |
| (+)-cis-EC (7) | 9.8 ± 0.5 a | 100 | 0 |
| (−)-cis-EC (8) | 8.3 ± 1.4 a | 87.5 | 0 |
| (+)-trans-EC (9) | 0.7 ± 0.7 a | 25 | 0 |
| (−)-trans-EC (10) | 0.0 ± 0.0 a | 12.5 | 0 |
The values represent the mean ± SEM (n = 8 in each group). a p < 0.001 for the epoxycarvone stereoisomers group (300 mg/kg) as compared to the control group (ANOVA One way/Tukey’s test). Fisher’s exact test was used to analyze the percentages of animals with seizures and the mortality rate.