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Key interaction and the crucial residues between mGluR1 NAMs and 4OR2_A.
| Hydrogen Bonding Interactions | Hydrophobic Interactions | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Group A | TRP798 | LEU757 | ARG661 | THR815 | THR794 | VAL664 | LEU757 | PHE801 | VAL753 | PRO756 |
| Group B | LEU757 | TRP798 | GLY665 | ARG661 | THR815 | VAL664 | VAL753 | LEU757 | ALA818 | PRO756 |
| Group C | ARG661 | GLY752 | THR815 | LEU757 | ASN760 | VAL664 | VAL753 | PRO756 | LEU757 | ARG661 |
