Table 3.

Peak activations group differences

Region	x	y	z	z-score	Cluster size
All trials: H > P
L caudate nucleus	−12	2	18	4.74	348
Memory effects: Group x retrieval success (H (Hits > CR) > P (Hits > CR))
Brain stem	−8	-36	−28	4.81	420
L LC	−6	−38	−30	3.75
R LC	8	−38	−28	3.64
L SN/VTA	−4	−20	−18	3.41
R Amygdala (LB [74])	30	0	−24	4.02	189
R anterior hippocampus (CA1 [74])	30	−8	−22	3.68
R posterior hippocampus (CA2 [74])	34	−34	−6	3.78a	11
Confidence effects: Group x confidence (P (HC > LC) > H (HC > LC))
L MFG	−26	32	24	5.27	2173
L SFG	−22	36	26	5.22
R SFG	16	32	40	4.54
R ACC	6	32	26	4.46
L ACC	−8	30	26	4.33
R SMA	10	14	68	4.56	230
R NAcc	10	14	−4	4.18b	27
R putamen	14	12	−6	3.93b	23
R caudate nucleus	12	14	−2	3.91b	36

x, y, z coordinates refer to the peak voxel in MNI space thresholded at P < 0.05 (FWE-corrected at the cluster level/small volume FWE-corrected). No significant activations were observed for the inverse contrasts.

R right, L left, H haloperidol, P placebo, LC locus coeruleus, SN/VTA substantia nigra/ventral tegmental area, MFG middle frontal gyrus, SFG superior frontal gyrus, ACC anterior cingulate gyrus, SMA supplementary motor area, NAcc nucleus accumbens

^aSmall volume FWE-corrected using the bilateral anatomical hippocampus mask

^bSmall volume FWE-corrected using the bilateral anatomical striatum mask.