Table 3.
Changes in cancer-related molecules after the administration of green tea polyphenols.
| Molecules | Type | Sample | Cell Line | Effect | Year [Ref] |
|---|---|---|---|---|---|
| Akt | TRAMP | Tissue | ↓ | 2004 [47]; 2009 [89] | |
| AR | TRAMP | Tissue | ↓ | 2007 [40] | |
| Xenograft | Tissue | CW22Rv1 | ↓ | 2011 [35] | |
| Bcl-2 | Xenograft | Tissue | CW22Rv1 | ↓ | 2006 [39]; 2007 [32] |
| TRAMP | Tissue | ↓ | 2008 [53] | ||
| Bax | Xenograft | Tissue | CW22Rv1 | ↑ | 2006 [39]; 2007 [32] |
| TRAMP | Tissue | ↑ | 2008 [53] | ||
| COX-2 | TRAMP | Tissue | ↓ | 2007 [40] | |
| E-cadherin | TRAMP | Tissue | ↑ | 2005 [109] | |
| Erk 1/2 | TRAML | Tissue | ↓ | 2004 [47]; 2007 [40]; 2009 [89] | |
| IGF-1 | TRAMP | Serum | ↓ | 2001 [37]; 2009 [89] | |
| TRAMP | Tissue | ↓ | 2004 [47]; 2007 [40]; 2009 [89] | ||
| Xenograft | Serum | CW22Rv1 | ↓ | 2007 [32] | |
| IGF-1R | TRAMP | Tissue | ↓ | 2007 [40] | |
| IGFBP-3 | TRAMP | Serum | ↑ | 2001 [37]; 2009 [89] | |
| TRAMP | Tissue | ↑ | 2004 [47] | ||
| Xenograft | Serum | CW22Rv1 | ↑ | 2007 [32] | |
| IKKα and β | TRAMP | Tissue | ↓ | 2008 [53] | |
| iNOS | TRAMP | Tissue | ↓ | 2007 [40] | |
| MCM7 | TRAMP | Tissues | ↓ | 2007 [127] | |
| miRNA-21 | Xenograft | Tissue | CW22Rv1 | ↓ | 2011 [34] |
| miRNA-330 | Xenograft | Tissues | CW22Rv1 | ↑ | 2011 [34] |
| NF-κB | Xenograft | Tissue | CW22Rv1 | ↓ | 2007 [32] |
| TRAMP | Tissue | ↓ | 2008 [53] | ||
| NIK | TRAMP | Tissue | ↓ | 2008 [53] | |
| PARP | Xenograft | Tissue | CW22Rv1 | ↑ | 2007 [32] |
| PI3K | TRAMP | Tissue | ↓ | 2004 [47] 2009 [89] | |
| PPARγ | Xenograft | Tissue | CW22Rv1 | ↓ | 2007 [32] |
| RANK | TRAMP | Tissue | ↓ | 2008 [53] | |
| STAT-3 | TRAMP | Tissue | ↓ | 2008 [53] | |
| S100A4 | TRAMP | Tissue | ↓ | 2005 [109] | |
| u-PA | TRAMP | Tissue | ↓ | 2004 [47] | |
| VEGF | Xenograft | Tissue | CW22Rv1 | ↓ | 2006 [39] |
| TRAMP | Tissue | ↓ | 2004 [47] |
AR, androgen receptor; Bcl, B-cell lymphoma; Bax, bcl-2-associated X protein; COX, cyclooxygenase; IGF, insulin-like growth factor; IGFBP, IGF-binding protein; iNOS, inducible nitric oxide synthase; MCM7, minichromosome maintenance protein; NFκB, nuclear factor kappa B; PARP, poly-ADP ribose polymerase; PPAR, peroxisome proliferator-activated receptor; STAT, signal transduction and activator of transcription; u-PA, urokinase-type plasminogen activator; VEGF, vascular endothelial growth factor.