Nutrition-specific and sensitive drivers of poor child nutrition in Kilte Awlaelo-Health and Demographic Surveillance Site, Tigray, Northern Ethiopia: implications for public health nutrition in resource-poor settings

ABSTRACT

Background: Child undernutrition is a prevalent health problem and poses various short and long-term consequences.

Objective: This study seeks to investigate the burden of child undernutrition and its drivers in Kilte Awlaelo-Health and Demographic Surveillance Site, Tigray, northern Ethiopia.

Methods: In 2015, cross-sectional data were collected from 1,525 children aged 6–23 months. Maternal and child nutritional status was assessed using the mid upper arm circumference. Child’s dietary diversity score was calculated using 24-hours dietary recall method. Log-binomial regression and partial proportional odds model were fitted to examine the drivers of poor child nutrition and child dietary diversity (CDD), respectively.

Results: The burden of undernutrition and inadequate CDD was 13.7% (95% CI: 12.1–15.5%) and 81.3% (95%CI: 79.2–83.1%), respectively. Maternal undernutrition (adjusted prevalence ratio, adjPR = 1.47; 95%CI: 1.14–1.89), low CDD (adjPR = 1.90; 95%CI: 1.22–2.97), and morbidity (adjPR = 1.83; 95%CI: 1.15–2.92) were the nutrition-specific drivers of child undernutrition. The nutrition-sensitive drivers were poverty (compared to the poorest, adjPR poor = 0.65 [95%CI:0.45–0.93], adjPR medium = 0.64 [95%CI: 0.44–0.93], adjPR wealthy = 0.46 [95%CI: 0.30–0.70], and adjPR wealthiest = 0.53 [95%CI: 0.34–0.82]), larger family size (adjPR = 1.10; 95%CI: 1.02–1.18), household head’s employment insecurity (adjPR = 2.10; 95%CI: 1.43–3.09), and residing in highlands (adjPR = 1.93; 95%CI: 1.36–2.75). The data show that higher CDD was positively associated with wealth (OR wealthy = 3.06 [95%CI: 1.88–4.99], OR wealthiest = 2.57 [95%CI: 1.53–4.31]), but it was inversely associated with lack of diverse food crops production in highlands (OR = 0.23; 95%CI: 0.10–0.57]).

Conclusions: Our findings suggest that the burden of poor child nutrition is very high in the study area. Multi-sectoral collaboration and cross-disciplinary interventions between agriculture, nutrition and health sectors are recommended to address child undernutrition in resource poor and food insecure rural communities of similar settings.

Background

Child undernutrition is the leading cause of child morbidity and mortality globally [1,2]. It is still a persistently prevalent health problem in Ethiopia [3–8] even though its burden shows a declining trend [9]. According to the Ethiopian Demographic and Health Survey (EDHS) 2000 and 2016 child wasting, an indicator of acute food deficit, showed only a 2% decline at national level, and persisted at 11.1% in Tigray regional state [9,10].

Multiple factors and their complex interactions result in child undernutrition. In brief, the literature shows that high household wealth status, maternal access to health services, child dietary diversification, food security, access to improved water and sanitation, better housing quality, prevention and timely treatment of acute malnutrition are strongly associated with optimal child nutrition and survival [11–22]. On the other hand, maternal nutritional insult, larger family size with short birth interval, the absence of diverse agricultural food crop production, living in highlands and childhood morbidity, were reported to be associated with child undernutrition [11,14,15,22–30].

Nutritional wellbeing and survival of children could also be jeopardized through household shocks after illnesses or mortality of adult household members. Children living in households with a substantial loss of household earnings, due to a high burden of sickness-induced loss of employment, were found to be severely undernourished [30]. A significantly higher risk of falling into poverty and food insecurity was also observed for households which experienced adult mortality from both chronic diseases as well as acute infectious diseases [31–33] and this could also negatively impact child nutritional status and wellbeing.

Left unaddressed, child undernutrition has several short and long-term consequences to those who are affected and their future generations [11]. Adverse early life due to child undernutrition was related to lower human capital, with a likely intergenerational transmission of poverty (IGTP) [34,35], and higher risks of developing non-communicable diseases (NCDs) during adulthood [34,36,37]. Therefore, ensuring the nutritional wellbeing and survival of children, particularly during the first 1000 days of life, is one of the substantiated public health strategies recommended for reducing present and future disease burden caused by malnutrition [2,38,39]. The main objectives of this study were to assess the burden and nutrition-specific and sensitive drivers of undernutrition as well as dietary diversity among 6–23 months old children in Kilte Awlaelo-Health and Demographic Surveillance Site (KA-HDSS), Tigray, northern Ethiopia.

Methods

Setting, study design and data sources

Detailed descriptions of the surveillance site (KA-HDSS) have been published in prior research works [40,41]. This study used cross-sectional data collected during the second census of the site, which was held 5 years after its establishment in 2009. The census data collects several socio-demographic, economic, environmental, and public health-related data. Using the site’s platform and its convenience for implementing other researches, baseline nutritional survey data of mothers and their children were collected as an add-on project. Concisely stated, nutrition-specific drivers refer to the immediate determinants of child nutrition and development, whereas nutrition-sensitive drivers refer to the underlying determinants mentioned in the UNICEF’s framework for child nutrition, health and survival [11,38].

Study population

All the 1,525 children aged 6–23 months form the study population.

Measurement of variables

Nutritional status of children and their corresponding mothers was assessed using the mid upper arm circumference (MUAC) measured in centimetre (cm). Maternal MUAC below 23 cm [29,42] is categorized as undernutrition and a maternal MUAC below 21 cm [42] as severe undernutrition. Studies have shown that measuring nutritional status of non-pregnant mothers using MUAC can be a good substitute for body mass index [42–44]. Since MUAC is significantly age and sex dependent, particularly for children < 24 months, the decision of determining nutritional status of children by absolute MUAC estimates is problematic and needs to be adjusted for these factors [45–48]. A study in 2018, based on 255,623 measurements of 19 surveys found that the estimates of acute undernutrition by age-sex adjusted MUAC and weight for-height/length Z-score (WHZ) was similar, unlike the estimates from the absolute MUAC values which were discrepantly lower [49]. Acknowledging the relevance of the methodological recommendations of the cited studies, in this study, children’s MUAC values were transformed to standardized z-score based MUAC (MUACZ) using WHO Anthro 2011 adjusting the age and sex of each child [50]. Then, child undernutrition was defined if the MUAC was <-2 z-score (MUAC <-3 z-score being defined as severe undernutrition and moderate undernutrition if the MUAC is <-2 to ≥-3 z-score). Biologically implausible MUACZ score values were dropped if the values fell out of the range of −5 and +5 [50]. Accordingly, two observations were dropped because their corresponding MUACZ scores were < −5.

Child’s dietary diversity score (CDDS) was calculated out of seven food groups using the 24-hrs dietary recall method [51]. The responses to each of the seven food groups were dichotomized (‘1’ if a given food group was consumed or ‘0’ if it was not consumed) and summed up to obtain the child dietary diversity score with values ranging from a minimum of 0 to a maximum of 7. This procedure was done using the World Health Organization (WHO) technique (51). Consumption of each food group was also disaggregated by age group of the children according to the WHO recommendation [52]. Then, in the model that examined the drivers of child undernutrition, child dietary diversity score was recoded as adequate (consumption of ≥4 food groups/day) and inadequate (consumption of <4 food groups/day) because consumption of four or more food groups was related to better diet quality [51,52]. However, in a separate model which analyzed the drivers of dietary intake of the young children, CDDS was categorized as low (consumption of <4 food groups), medium (consumption of 4 to 5 food groups), and high (consumption of ≥6 food groups) [53–55].

Socio-economic position was measured using wealth index, applying principal component analysis [56,57], from a wide range of variables such as accessibility to improved water and sanitation services as defined by the WHO/UNICEF Joint Monitoring Program (JMP) ladders [58], levels of housing quality computed by replicating a prior research work [59], availability and quantity of agricultural ownership (farmland, bee hive, cart, livestock and food crops produced), access to electricity, media (created from single or joint ownership of TV or radio or phone), and other household ownerships like a bed with sofa, use of non-biomass energy source for food cooking etc. Detail of our methodology for generating wealth index is provided in Appendix D of the supplementary material.

The variable maternal health-seeking practice (mHSP) was constructed from two variables (current use of modern contraceptive and maternal tetanus toxoid immunization during pregnancy) and its values range from 0 to 2. This proxy variable was then dichotomized as ‘good practice’ if the score was 2 (mother used both maternal health services) and ‘poor practice’ if the score was less than 2 (mother used either none or only one of the two maternal health services). Altitudinal location of households was measured using geographic positioning system (GPS) and classified as highland (≥2, 300 meter) and low/midland (<2, 300 meter) [41]. Causes of adult death (CoD) were identified using physician review method and classified according to International Classification of Diseases version 10 (ICD-10) [60]. In this paper, the specific causes of death are then operationally reclassified as chronic causes (NCDs including cancer, cardio-vascular diseases, diabetes, and chronic lung diseases as well as chronic infectious diseases including TB and HIV/AIDS) and other causes (all acute infectious diseases, external causes, unspecified causes, undetermined and pregnancy-related CoD) primarily based on the chronicity of the CoD. The rationale underlying this classification is due to the difference in the length of the duration of illness of the CoD, which is primarily determined by the nature of the expected course of duration from clinical-stage development to the time of death. The assumption was that mortality from chronic CoD might have caused a differentially immense household level negative impacts, over the possibly longer period of illness of the deceased adults, and thereby distinctively expose the young children to undernutrition [30,61,62].

Statistical analyses

Modeling of child undernutrition was performed using generalized linear regression with a log link and binomial distribution. This statistical procedure was chosen, compared to the most commonly used binary logistic regression, because if the outcome is not rare (outcome > 10%), odds ratio (OR) can no longer approximate the risk ratio and is not an appropriate measure of association. Therefore, in studies with common outcomes, prevalence ratio (PR) should be used to measure an association [63,64]. In this study, the prevalence of child undernutrition (defined by MUAC <-2 z-score) was 13.7% which indicates that, in the study setting, the outcome of our interest is not a rare condition. Next, a proportional odds model (POM) was performed to identify the factors associated with child dietary diversity score. This statistical procedure was chosen as opposed to other modeling options, such as multinomial model or multivariable binary logistic regression model, because CDDS is a polychotomous variable with meaningfully inherent order. Thus, multinomial procedure was not used. POM is a more parsimonious, efficient and appropriate model than running multiple separate binary logistic regression models [65,66]. The POM convergence problem was avoided using the ‘difficult’ command option in Stata 13.0 [64]. Then, brant test was used to assess the proportional odds/parallel-lines assumption of each variable. Using this test, the variable ‘geographic location’ had a significant p-value indicating that this variable violated the parallel-lines assumption of POM and hence a partial proportional odds model (PPOM), with gamma parametrization method, was fitted by un-constraining this variable and constraining all other variables. The interpretation of ‘geographic location’ variable based on the PPOM model has enabled us to identify its pattern of association with the outcome variable, which otherwise would have remained obscured in the POM. Evidence of multicollinearity was assessed using variance inflation factor (VIF) at cut-off value of greater than 10 [67] and no collinearity was found as reported in Appendix F1 of the supplementary material. In the univariable analysis of both models, all variables with a p value of < 0.25 were selected [68,69] and fitted into the multivariable models in which statistical significance was declared at p value of <0.05.

Results

Details of household level including socio-economic, agricultural, and epi-demographic characteristics are presented in Table A1. Generally, increasing pattern of quintile wealth index was observed for the households with access to infrastructural service and improved public health indicators such as availability of electricity, improved housing quality, kitchen and non-biomass cooking fuel (Table A1).

Causes of adult death

Of the total 1,525 surveyed households, 91 (6 %) of the households had a history of death of an adult household member who deceased between 2009 and 2015. About half of the adult deaths, 45 (49.5%) were due to chronic diseases and the remaining 46 were due to other causes.

Young child undernutrition

This study focused on children from 6 months to 23 months of age. Almost half of the children were female (50.5 %). The mean (and standard deviation, SD) age of the study participants was 13.5 ± 4.9 months (13.5 ± 5.0 months for females and 13.4 ± 4.8 months for males). Out of the total 1, 525 study participants, 209 children, 13.7% (95% CI: 12.1–15.5%), were undernourished of which 43 (20.6%) were of a severe form. The burden of undernutrition was higher among male children compared to females (15.9% vs 11.6%, p = 0.014). The mean (SD) child MUACZ score was −0.87 (1.13). The distribution of MUACZ score of the study children was left shifted as compared with the Z-scores of WHO standard (Figure B1).

Based on MUAC cut off value of < 23 cm 39.9% (95% CI: 37.5–42.4) of the children’s mothers were undernourished and 102 (16.9%) of these mothers were severely undernourished (MUAC < 21 cm). Access to adequate child dietary diversity was 18.7% (95%CI: 16.9–20.8%). Consumption of fruits and vegetables rich in vitamin A (3.3 % vs 10.1 %; p = 0.002) and dairy food (19.4% vs 31.5%, p < 0.001) was significantly lower for the undernourished children compared to those who were not (data not shown). As presented in Table 1, the burden of undernutrition was higher among young children who had lower mean dietary diversity intake and whose mothers were undernourished. Child undernutrition was also relatively high among those who were living in households which had lower wealth quintiles, higher mean family size, located in highlands, and living in households which experienced symptomatic morbidity (cough, diarrhea, fever, and/or any other symptom) and produced no diverse food crops (Table 1).

Table 1.

Nutritional status of children by selected independent variables, KA-HDSS, Tigray, northern Ethiopia (n = 1, 525).

Characteristics	Categories	Row distribution of Nutritional status of children, n (%)		Column total, n (%)
		MUAC ≥-2 z-score	MUAC <-2 z-score
Residence	Semi-urban	80 (94.1)	5 (5.9)	85 (5.6)
	Rural	1,236 (85.8)	204 (14.2)	1, 440 (94.4)
Sex of household head	Male	1,137 (85.8)	188 (14.2)	1, 325 (86.9)
	Female	179 (89.5)	21 (10.5)	200 (13.1)
Sex of child	Male	635 (84.1)	120 (15.9)	755 (49.5)
	Female	681 (88.4)	89 (11.6)	770 (50.5)
Educational status of household head	No formal education	886 (85.8)	146 (14.2)	1, 032 (67.7)
	Formal education	428 (87.2)	63 (12.8)	491 (3.2)
	Missing			2 (0.1)
Occupation of household head	Farmer/housewife	1,123 (86.9)	169 (13.1)	1,292 (84.7)
	Daily laborer	110 (76.9)	33 (23.1)	143 (9.4)
	Government employee and others	83 (92.2)	7 (7.8)	90 (5.9)
Mean age of household head in years (SD)		42.3 (11.1)	44.8 (11.5)	1, 525
Mean child dietary diversity score		2.2 (1.5)	1.9 (1.3)	1, 525
Maternal MUAC	normal	814 (89.6)	94 (10.4)	908 (60.1)
	Undernourished	491 (81.3)	113 (18.7)	604 (39.9)
History of adult death	No history adult death	1,234 (86.0)	200 (14.0)	1, 434 (94.0)
	Yes-from chronic diseases	40 (88.9)	5 (11.1)	45 (2.9)
	Yes- from acute infectious diseases, injuries and other causes	42 (91.3)	4 (8.7)	46 (3.0)
Mean quintile wealth status (SD)		3.1 (1.4)	2.5 (1.4)	1, 483
Geographic location	Low/midland	906 (87.3)	132 (12.7)	1, 038 (68.1)
	Highland	306 (81.6)	69 (18.4)	375 (24.6)
	Missing			112 (7.3)
Morbidity history in the past 2 weeks	No	1,274 (86.7)	195 (13.3)	1, 469 (96.3)
	Yes	41 (74.5)	14 (25.5)	55 (3.6)
	Missing			1 (0.07)
Mean household size (SD)		6.2 (2.0)	6.8 (1.9)	1, 525
No crop/monocrop production	Yes	575 (83.8)	111 (16.2)	686 (45.0)
	No	741 (88.3)	98 (11.7)	839 (55.0)

Patterns of nutritional outcomes and morbidity by age and sex

The percentage of occurrence of morbidity was higher in the households where the boys resided as compared to the households where the girls resided, 4.8 % vs 2.5 % respectively. Boys were living in 65.5 % of the total households which reported occurrence of morbidity. Except for the boys in the age groups of 9–11 months and 12–14 months, reports of occurrence of morbidity were lower for the girls compared to all other age groups (Figure 1).

Figure 1.

Distribution of households’ experience of morbidity by sex and age of children, KA-HDSS, Tigray, northern Ethiopia (n = 1, 525).

As shown in Figure 2, the mean MUACZ score values of boys was consistently lower than that of girls across all age groups. In addition, the mean CDDS of girls was either higher or equal to that of the boys except for the 9–11 months age group (Figure 2).

Figure 2.

Patterns of mean child dietary diversity score (CDDS) and MUACZ score by sex and age of children, KA-HDSS, Tigray, northern Ethiopia (n = 1, 525).

Determinants associated with child undernutrition

We found that various determinants were significantly associated with child undernutrition including: maternal undernutrition (adjPR = 1.47; 95%CI: 1.14–1.89), inadequate child dietary diversity (adjPR = 1.90; 95%CI: 1.22–2.97), daily laborer occupation of household head (adjPR = 2.10; 95%CI: 1.43–3.09), and occurrence of morbidity among a family member (adjPR = 1.83; 95%CI: 1.15–2.92) (Table 2). Furthermore, higher family size (adjPR = 1.10; 95%CI: 1.02–1.18) and residing in highlands (adjPR = 1.93; 95%CI: 1.36–2.75) were also significantly associated with a higher burden of undernutrition. However, the effect of highland geographic location was significantly modified by the diverse food cropping practice of households. Compared to lowlander children living in households with no crop or monocrop production, highlander children who lived in households that produced more than one type of food crop had a significantly lower prevalence of undernutrition (adjPR = 0.42; 95%CI: 0.23–0.77) (Table 2).

Table 2.

Prevalence ratios (PR) for the determinants of child undernutrition using crude and adjusted (for all the variables in the table) GLM log-binomial model, KA-HDSS, Tigray, northern Ethiopia (n = 1, 525).

Variables	Categories	Undernutrition
		Crude PR (95% CI)	p-value	Adjusted PR (95% CI)	p-value
Residence	Urban	1.00		1.00
	Rural	2.41 (1.02, 4.45)	0.045	1.77 (0.62, 5.04)	0.286
Sex of household head	Male	1.00		1.00
	Female	0.74 (0.48, 1.13)	0.166	0.86 (0.56, 1.31)	0.472
Maternal health-seeking practice	Poor	1.00		1.00
	Good	0.76 (0.55, 1.05)	0.098	0.92 (0.66, 1.27)	0.615
Age of household head (5-year increase)		1.08 (1.03, 1.14)	0.002	1.03 (0.97, 1.10)	0.358
Occupation of household head	Farmer	1.00		1.00
	Daily laborer	1.76 (1.27, 2.46)	0.001	2.10 (1.43, 3.09)	<0.001
	Government employee and other occupations	0.60 (0.29, 1.23)	0.160	1.75 (0.75, 4.08)	0.196
Child dietary diversity score	Adequate	1.00		1.00
	Inadequate	1.87 (1.23, 2.82)	0.003	1.90 (1.22, 2.97)	0.005
Maternal undernutrition	No	1.00		1.00
	Yes	1.81 (1.40, 2.33)	<0.001	1.47 (1.14, 1.89)	0.003
Wealth index	Poorest	1.00		1.00
	Poor	0.54 (0.38, 0.77)	0.001	0.65 (0.45, 0.93)	0.020
	Medium	0.52 (0.36, 0.74)	<0.001	0.64 (0.44, 0.93)	0.019
	Wealthy	0.35 (0.23, 0.54)	<0.001	0.46 (0.30, 0.70)	<0.001
	Wealthiest	0.42 (0.28, 0.62)	<0.001	0.53 (0.34, 0.82)	0.004
History of adult death in household	No history of death	1.00		1.00
	Chronic diseases	0.80 (0.35, 1.84)	0.594	0.96 (0.42, 2.17)	0.918
	Acute, external and other causes	0.62 (0.24, 1.60)	0.327	0.61 (0.24, 1.53)	0.292
Geographic location	Lowland	1.00		1.00
	Highland	1.45 (1.11, 1.89)	0.007	1.93 (1.36, 2.75)	<0.001
Two weeks history of morbidity	No	1.00		1.00
	Yes	1.92 (1.20, 3.07)	0.007	1.83 (1.15, 2.92)	0.012
Household size		1.13 (1.06, 1.20)	<0.001	1.10 (1.02, 1.18)	0.016
No crop or monocrop production	Yes	1.00		1.00
	No	0.72 (0.56, 0.93)	0.011	1.00 (0.70, 1.43)	0.999
Highland#variety crop production (yes)		0.56 (0.35, 0.90)	0.018	0.42 (0.23, 0.77)	0.005

In comparison with the children who lived in the poorest households, those who lived in the poor, medium, wealthy, and wealthiest households had 0.65, 0.64, 0.46, and 0.53 times lower risk of child undernutrition. Moreover, history of adult death from both chronic and other CoD were not found to be associated with child undernutrition (Table 2).

Child dietary diversity by sex and age

Majority of the study participants, 81.3% (95% CI: 79.2, 83.1), had an inadequate dietary diversity. High child dietary diversity (≥6 food groups per day) was commonly observed among children whose household heads were married, wealthier households and children residing in low or midland geographic location (Table C1). The least consumed food groups among children in this study were fleshy (6.2 %) and vitamin A rich fruits and vegetables (9.2 %). Whereas, consumption of grains, roots, and tubers (89.8%) and eggs (43%) were considerably higher. Other food groups such as dairy foods, legumes and nuts, and other fruits and vegetables were consumed to 29.8 %, 23.3 % and 14.4 %, respectively. There was no significant difference found among consumption of each food group by sex, except for consumption of eggs, which was found to be more common among the female children (45.9% vs 40%, p = 0.018).

The consumption of each food group when disaggregated by age group of the children showed statistical significance (p < 0.01). We found that dairy foods, eggs, grains, roots and tubers were more likely to be offered to the younger age groups, while fleshy and vitamin A rich foods were more frequently consumed by the oldest age group (Figure 3).

Figure 3.

Proportion of children who consumed each food group per day by age group, KA-HDSS, Tigray, northern Ethiopia (n = 1,525).

Determinants associated with child dietary diversity (CDD)

Children from the wealthiest and wealthy households had 2.57 (OR = 2.57; 95% CI: 1.53–4.31) and 3.06 (OR = 3.06; 95% CI: 1.88–4.99) times greater odds of having a higher dietary diversity compared to children from poorest households, respectively, given the other variables are held constant. Another factor that influenced the likelihood of a lower dietary diversity was when the household head was not in a marital relationship, but this association did not fully rule out the role of chance (Table 3).

Table 3.

Results from partial proportional odds model (POM) using child dietary diversity score with three ordered categories, KA-HDSS, Tigray, northern Ethiopia (n = 1, 525).

Variables	Categories	High CDDS vs (low and medium CDDS)		High and medium CDDS vs (low CDDS)
		Adjusted OR (95% CI)	p-value	Adjusted OR (95% CI)	p-value
Household size		1.05 (0.96, 1.13)	0.297	1.05 (0.96, 1.13)	0.297
Maternal health-seeking practice	poor practice	1.00		1.00
	Good practice	1.07 (0.78, 1.45)	0.678	1.07 (0.78, 1.45)	0.678
Household head occupation	Farmer
	Daily laborer	0.77 (0.46, 1.30)	0.330	0.77 (0.46, 1.30)	0.330
	Govt. employee and all others	0.88 (0.47, 1.67)	0.704	0.88 (0.47, 1.67)	0.704
Wealth status	Poorest	1.00		1.00
	Poor	1.09 (0.64, 1.86)	0.759	1.09 (0.64, 1.86)	0.759
	Medium	1.49 (0.90, 2.46)	0.124	1.49 (0.90, 2.46)	0.124
	Wealthy	3.06 (1.88, 4.99)	<0.001	3.06 (1.88, 4.99)	<0.001
	Wealthiest	2.57 (1.53, 4.31)	<0.001	2.57 (1.53, 4.31)	<0.001
History of adult death	No history of adult death	1.00		1.00
	Death from chronic diseases	1.08 (0.51, 2.27)	0.841	1.08 (0.51, 2.27)	0.841
	Death from acute, external and other causes	1.20 (0.54, 2.65)	0.662	1.20 (0.54, 2.65)	0.662
Geographic location*	Low/midland	1.00		1.00
	Highland	0.23 (0.10, 0.57)	0.002	1.17 (0.74, 1.84)	0.510
Farmland size	≤2 ha	1.00		1.00
	>2 ha	1.28 (0.91, 1.80)	0.151	1.28 (0.91, 1.80)	0.151
Variety crop production (yes)#highland geographic location		2.92 (1.75, 4.85)	<0.001	2.92 (1.75, 4.85)	<0.001
Marital status of household head	Married	1.00		1.00
	Not in marital relationship	0.59 (0.33, 1.06)	0.078	0.59 (0.33, 1.06)	0.078

*Gamma_2 value is significant (p < 0.001) for the variable ‘Geographic location’; it violates the parallel-lines assumption of the POM

As shown in Table 3, the variable ‘geographic location’ violates the parallel-lines assumption of the proportional odds model. Therefore, the interpretation of the pattern of association of this variable with the outcome variable should be based on its unconstrained effect. Accordingly, highlanders compared to lowlanders showed a 0.23 (OR = 0.23; 95%CI: 0.10–0.57) times lower likelihood of having a high vs the combined medium and low dietary diversity. However, the likelihood of the combined high and moderate dietary diversity vs low dietary diversity was 1.17 (OR = 1.17; 95%CI: 0.74–1.84) times higher for highlanders as compared to lowlanders. Additionally, for a unit increase in food crops variety in the highlanders, that is, going from monocrop/no crops production to variety crops production and going from lowland to highland, the odds of having better dietary diversity was found to be 2.92 (OR = 2.92: 95%CI: 1.75–4.85) times higher given that the other variables fitted in the model are held constant.

Discussion and conclusion

This study examined the burden and drivers of poor child nutrition among children aged 6–23 months in KA-HDSS, northern Ethiopia. The prevalence of child undernutrition (13.7 %) and inadequate child dietary diversity (< 4 food groups/day) (81.3%) was found to be high in our study setting. Key nutrition specific drivers of undernutrition included maternal undernutrition, inadequate access to child dietary diversity, and occurrence of morbidity. Furthermore, the principal nutrition-sensitive drivers of undernutrition were household poverty, larger family size, daily laborer occupation of household head, residing in highlands (≥ 2,300 meter) particularly where no diverse food crop production farming was practiced. Moreover, higher child dietary diversity (≥ 6 food groups/day) was positively associated with better wealth status and diverse food crops production.

In the study area, the prevalence of acute child undernutrition (MUAC<-2 z-score) was higher than the regional and national prevalence [9]. It is also considerably higher than the WHO’s 2025 target of ‘reduce and maintain childhood wasting to less than 5%’ [70]. Although the WHO’s target for wasting, which is based on WHZ<-2 z-score, is not identical with MUAC<-2 z-score, these two nutritional indices were shown to have similar performance in diagnosing acute child undernutrition [71]. Wasting among young children is associated with later detrimental effect on skeletal growth subsequent to linear growth retardation [72,73], and especially its concurrence with stunting, predicts high risk of child mortality [74,75]. Moreover, evidence on developmental origins of health and disease (DOHaD) revealed that survivors of severe acute undernutrition were reported to show traits of thrifty growth in later life [37], specifically, the association of early childhood infections and growth failure with elevated cardiovascular risk factors during adulthood is novel [34,36]. Considering the short and long-term deleterious impacts of wasting, addressing its key drivers could enormously enhance young child survival and wellbeing in the study setting.

The sex-specific analysis of undernutrition showed that boys were evidently more disadvantaged than girls. Our result accords with the findings of other studies [75–77], but it is inconsistent with the study from elsewhere [78], which also reported child age as an important factor. On the other hand, other studies from north Ethiopia reported no sex-differential of wasting, but of stunting [26,72]. Researchers explained that sex-specific differential burden of child undernutrition could be a manifestation of the complex interplay of the biologically higher vulnerability of males to symptomatic infectious illnesses and various context-specific factors such as cultural practices [26,79]. The apparently higher morbidity exposure of boys and relatively higher intake of quality diets by girls, reported in this study, might partly explain the observed nutritional inequality. Yet, further understanding of the underlying factors of the observed sex-specific inequality of child undernutrition, using qualitative research approach and longitudinal quantitative measurements accounting for the transitory nature of wasting, could have vital implications to public health nutrition policy and decisions aimed at addressing health inequity and ensuring nutritional wellbeing of all young children.

Adequate dietary diversity is a useful indicator of dietary quality and nutrient intake for infants and young children [18,51,80]. More than four-fifths of the participants of this study had no access to adequate dietary diversity, and this finding is markedly lower than the national estimation by Aemro et.al, which was 89.2% [19]. Similar to previous studies, inadequate access to child dietary diversity is found to be a strong predictor of child undernutrition [18,22]. Our finding shows a significantly lower consumption of some nutrient dense foods such as dairy, fruits and vegetables rich in vitamin A by the undernourished children. This might have co-exposed them to various deleterious risk factors (mainly infections like diarrheal diseases) that could influence their nutritional wellbeing [11,81]. In general, the study area is one of the most food insecure parts of Ethiopia, and pro-poor-oriented policy level developmental programs have been shown to be promising in ensuring household food security [82–84]. On top of such policy efforts, the implementation of home-based nutrition-sensitive interventions (home gardening, effective safety net programs together with asset and income-generating activities to poor households) and advancing maternal knowledge on child feeding practices may sustainably improve child nutritional status in such food insecure settings [5,12,38,81,83–87].

Many studies revealed that maternal nutritional status determines birth outcomes and neonatal survival, and has a pivotal role in fetal and child nutrition and development [2,12,29,81,88]. Consistent with these findings, our study indicates that children of undernourished mothers (MUAC < 23cm) were also more likely to suffer from undernutrition in contrast to those whose mothers were not undernourished. This may highlight the constitutive importance of promoting maternal-child dyad nutrition to substantially address young child undernutrition. The implementation of high impact maternal nutritional interventions could have indispensable inputs to reduce the burden of young child undernutrition and mortality [2,12,34]. Another notable finding of this study is the significant negative association of households’ morbidity experience with the young children’s nutritional wellbeing. Likewise, other studies identified that morbidity is considered to be one of the vital nutrition-specific determinant of child undernutrition, mainly due to its effect on dietary intake and nutrient utilization [11,25,27]. However, because of the limitation of our study design, we are not able to confirm if morbidity had resulted in child undernutrition or vice versa.

In line with other research findings [13,16,18,29,89], the current study has identified that higher household wealth status was associated with lower risk of child undernutrition. This association is independent of the effect of access to quality diet [18,90], a robust indicator of child undernutrition, and that wealth status may have influenced child nutritional status through multiple other pathways. As presented in our results, one such pathway could be the influence of wealth status on housing quality. This underscores the cross-functional role of household wealth on promoting young child nutrition by addressing the various nutrition-sensitive determinants of child undernutrition.

Higher family size was one of the strong nutrition-sensitive drivers of child undernutrition. This broadly substantiates the findings of previous studies [13,27,90,91]. In this study, the mean family size was differentially higher in the households where family planning (FP) was not utilized compared to the households where FP use was practiced (6.4 vs 5.9, p < 0.001). These findings imperatively call for making FP into effect to promote good nutritional status of mothers and their children [21,91]. The inverse association of household heads’ employment insecurity with undernutrition and poor child dietary diversity is direct [17,22]. As similarly reported by other studies [24,28], the burden of undernutrition was significantly higher among highlanders. Our data suggest better access to housing quality, media, sanitation, and electricity services by the low and/or midland households as compared to the highland households could have contributed to the higher burden of undernutrition among the highlanders as compared to their counterparts. However, the association of residing in highlands with child undernutrition strongly decreases in households which practiced diversified food crop production. This clearly shows that interventions targeting the agricultural sector to become nutrition-sensitive could potentially accelerate long-lasting effect for ameliorating child undernutrition, particularly if it is linked with the nutrition-specific interventions [12,38,92]. Despite our expectation, we did not find a statistically meaningful difference in the burden of child undernutrition by history of adult death, and the small adult death events in the study households might have limited the ability to detect its effect on child undernutrition.

Our study identified that inadequate child dietary diversity, maternal undernutrition and occurrence of morbidity were the robust nutrition-specific drivers, whereas, household poverty, household heads’ employment insecurity, larger family size, residing in highland households especially where no diverse food crops production was practiced were the strong nutrition-sensitive drivers of child undernutrition. The findings strongly suggest that intervention efforts aiming to reduce young child undernutrition should jointly address the examined nutrition-specific and sensitive drivers. For the success of such efforts in resource poor and food insecure rural settings, strong trans-sectoral collaborations and cross-disciplinary interventions, for instance the implementation of holistic developmental intervention programs and further interdisciplinary researches by the agriculture, nutrition and health sectors, could be highly important. The analysis of the effect of a wide range of possible drivers and the completion of the study before the 2016/17 el Nino shock, which may reflect the drivers of young child undernutrition under relatively stable conditions, are the major strengths of this study. However, due to the cross-sectional design of the study, the revealed relationships are only associational, and hence causality cannot be claimed.

Responsible Editor Peter Byass, Umeå University, Sweden

Funding Statement

The surveillance site, where the first author works as a research team member, has been funded by the Centers for Disease Control and Prevention (CDC-Ethiopia) through Ethiopian Public Health Association (EPHA) in accordance with the EPHA-CDC Cooperative Agreement No.5U22/PS022179_05, and Mekelle University. The first author’s PhD stipend has been covered by DAAD through the Food Security Center (FSC) at the University of Hohenheim, Germany. All the funders had no role in the design of the study, data collection and analysis, preparation of the manuscript, or decision to publish.

Acknowledgments

The authors are thankful to the study participants and data collectors of KA-HDSS. We acknowledge the funding support of the Centers for Disease Control and Prevention (CDC) through the Ethiopian Public Health Association (EPHA) and Mekelle University provided to KA-HDSS, where this data were extracted. We also sincerely appreciate Purdue University Center for Global Food Security for funding the publication cost of this research work. The first author got a PhD scholarship opportunity from DAAD through the Food Security Centre (FSC) at the University of Hohenheim and we are also pleased to acknowledge this support.

Author contributions

SFA, EJA, AMB, AAG, GE, JL, AW, and VS have substantial contributions to the conception or design of the work, the acquisition, analysis, interpretation of the data for the work; and drafting the work or revising it critically for important intellectual content; and final approval of the version to be published; and agreed to be accountable for all aspects of the work in ensuring that questions related to the integrity of any part of the work are appropriately investigated and resolved.

Disclosure statement

No potential conflict of interest was reported by the authors.

Ethics and consent

KA-HDSS was established with the ethical approval from Ethiopian Science and Technology Agency with an identification number of IERC-0030. Verbal consent was obtained from all the study participants. The Health Research Ethics Review Committee (HRERC) in Mekelle University also approved this study.

Paper context

Acute child undernutrition remains a persistently prevalent health problem in Tigray region, where over the course of 16 years, its burden showed no change. The prominent added value of this paper is that it has identified the nutrition-specific and sensitive determinants of young child undernutrition by examining a wide range of socio-economic, epi-demographic, agricultural, and other nutritional factors. Joint interventions by the agriculture, nutrition and health sectors are urgently needed to address young child undernutrition.

Supplementary material

Supplementary data for this article can be accessed here.