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. 2018 Oct 19;8(2):e1527498. doi: 10.1080/2162402X.2018.1527498

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Figure 1. — Distribution of NK cell subsets in the blood of NSCLC patients.

Representative flow cytometry gating strategy and proportion of circulating (A) total CD3⁻ CD56⁺ NK cells among PBMCs in HD (n = 41) and NSCLC patients (n = 176); and (C) CD56^dim CD16⁺, (D) CD56^dim CD16⁻ and (E) CD56^bright CD16⁻ NK cell subsets among total NK cells in HD (n = 41) and NSCLC patients (n = 176). (B) Frequency of each NK cell subsets in blood of HD (n = 41) and NSCLC patients (n = 176) represented by stacked bars. (F) Proportion of total NK cells among PBMCs and proportions of CD56^dim CD16⁺, CD56^dim CD16⁻ and CD56^bright CD16⁻ NK cell subsets among total NK cells in NSCLC patients according to the disease stage. Statistical analysis were performed using the Mann-Whitney test (two groups) or the Kruskal-Wallis test (more than two groups) (ns = not significant; ** P < 0.01; *** P < 0.001).