Table 3.
Genes downregulated in SKOV3 tumors treated with anti-TGFBR2 IgG-8311.
| Name | p value* | fold change* | TGF-β pathway* |
|---|---|---|---|
| IL6 | 0.027 | −3.176 | yes |
| CXCR4 | 0.05 | −1.788 | yes |
| PTPRB | 0.005 | −1.688 | |
| ZC3H12A | 0.021 | −1.678 | |
| ELF3 | 0.007 | −1.637 | |
| F3 | 0.01 | −1.596 | yes |
| SLC2A1 | 0.027 | −1.423 | |
| LAMC2 | 0.03 | −1.411 | |
| DST | 0.02 | −1.381 | |
| LAMB3 | 0.004 | −1.365 | yes |
| LAMA3 | 0.008 | −1.348 | |
| MET | 0.025 | −1.334 | |
| CLDN4 | 0.032 | −1.332 | |
| CCBE1 | 0.03 | −1.33 | |
| MYLK | 0.033 | −1.317 | yes |
| ITGA3 | 0.013 | −1.315 | yes |
| HKDC1 | 0.006 | −1.302 | |
| ANXA2P2 | 0.026 | −1.284 | |
| LGALS1 | 0.022 | −1.265 | |
| SMAD3 | 0.038 | −1.242 | yes |
| ALOX5 | 0.006 | −1.195 |
*based on Nanostring analysis of tumor RNA for IgG-8311 treatment group relative to control IgG