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. 2019 Jan 25;294(4):1433. doi: 10.1074/jbc.W118.007327

Withdrawal: Identification of human aminopeptidase O, a novel metalloprotease with structural similarity to aminopeptidase B and leukotriene A4 hydrolase.

Araceli Díaz-Perales, Víctor Quesada, Luis M Sánchez, Alejandro P Ugalde, María F Suárez, Antonio Fueyo, Carlos López-Otín
PMCID: PMC6349125  PMID: 30808004

VOLUME 280 (2005) PAGES 14310–14317

This article has been withdrawn by the authors upon request from the Journal. The Journal raised questions regarding Fig. 4, A and B. The authors were able to locate the original autoradiographs corresponding to Fig. 4A, detecting two duplicated GAPDH control bands. In Fig. 4B, an actin lane appears to be duplicated. Since the original data for the experiment shown in Fig. 4B, performed 13 years ago, could not be found, the authors state that a new experiment was performed using RNA from mouse testis from different ages (10–74 days). The authors state that the AP-O expression results concur with an RNA-seq–based transcriptomic analysis reported independently by other researchers (Margolin et al. (2014) BMC Genomics 15, 39). The authors assert that all of the results reported in this article are valid.


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