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The Journal of Biological Chemistry logoLink to The Journal of Biological Chemistry
. 2019 Jan 25;294(4):1430. doi: 10.1074/jbc.W118.007324

Withdrawal: Matriptase-2, a membrane-bound mosaic serine proteinase predominantly expressed in human liver and showing degrading activity against extracellular matrix proteins.

Gloria Velasco, Santiago Cal, Victor Quesada, Luis M Sánchez, Carlos López-Otín
PMCID: PMC6349132  PMID: 30808001

VOLUME 277 (2002) PAGES 37637–37646

This article has been withdrawn by the authors upon request from the Journal. In Fig. 6, a duplicated image of the lane corresponding to untreated fibrinogen was used in the PMSF-inactivated Matriptase-2 lane. In Fig. 8, actin panels were reused from previous publications of the group using the same commercial membranes, and the actin panel for the Northern blot containing spleen, thymus, prostate, testis, ovary, intestine, colon, and leukocyte samples was rotated 180 degrees. The liver-specific expression of Matriptase-2/TMPRSS6 shown in Fig. 8 can be compared to independent global RNA-seq studies (GTEx portal, https://www.gtexportal.org/home/gene/TMPRSS6). The authors assert that all of the results reported in this article are valid.


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