. 2018 Nov 16;11(1):183–200. doi: 10.1039/c8mt00239h

Table 2. All proteins whose abundances were significantly changed after growth for 6 h in TSB medium in the presence of 2.5 mM CuSO₄, relative to control cells in TSB alone, as determined by LC-MS/MS. Column ‘P’ shows statistical significance using the Fisher's exact test.

Protein	Gene	ORF	GI	Fold	P
Proteins with increased abundance in cells cultured in 2.5 mM Cu in TSB medium
Copper-exporting P-type ATPase	copA	SAOUHSC_02873	gi\|122538628	ON	<0.00010
30S ribosomal protein S15	rpsO	SAOUHSC_01250	gi\|118597468	12	<0.00010
30S ribosomal protein S12	rpsL	SAOUHSC_00527	gi\|447065081	9	<0.00010
Copper chaperone CopZ	copZ	SAOUHSC_02874	gi\|122538627	6.9	<0.00010
Superoxide dismutase [Mn/Fe] 2	sodM	SAOUHSC_00093	gi\|123003520	6.7	0.00025
Virulence factor EsxA	esxA	SAOUHSC_00257	gi\|447163570	3.1	<0.00010
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	fabI	SAOUHSC_00947	gi\|122539868	3.1	<0.00010
Alkyl hydroperoxide reductase subunit C	ahpC	SAOUHSC_00365	gi\|60391219	2.2	<0.00010
Fructose-bisphosphate aldolase	fda	SAOUHSC_02926	gi\|446954157	2.2	<0.00010
Transketolase	tkt	SAOUHSC_01337	gi\|446403588	2	<0.00010
Alkyl hydroperoxide reductase subunit F	ahpF	SAOUHSC_00364	gi\|3913011	1.8	<0.00010
Cysteine synthase	cysK	SAOUHSC_00488	gi\|445979739	1.7	<0.00010
Hypothetical protein	—	SAOUHSC_00906	gi\|122539893	1.7	0.00078
Glyceraldehyde-3-phosphate dehydrogenase A	gapA	SAOUHSC_00795	gi\|446201559	1.3	<0.00010

Proteins with decreased abundance in cells cultured in 2.5 mM Cu in TSB medium
Elongation factor Tu	tuf	SAOUHSC_00530	gi\|123098060	0.8	<0.00010
Elongation factor G	fusA	SAOUHSC_00529	gi\|119368769	0.7	<0.00010
DNA-directed RNA polymerase subunit beta′	rpoC	SAOUHSC_00525	gi\|114152142	0.7	0.00032
Bifunctional autolysin	atl	SAOUHSC_00994	gi\|110832765	0.7	<0.00010
Formate-tetrahydrofolate ligase	fhs	SAOUHSC_01845	gi\|122540563	0.7	0.00025
Cold-shock protein [bacteria]	cspC	SAOUHSC_00819	gi\|446981826	0.5	0.0001
NADH dehydrogenase-like protein	ndh2	SAOUHSC_00878	gi\|122539909	0.5	0.00012
Adenylosuccinate synthetase	purA	SAOUHSC_00019	gi\|446017472	0.4	0.00011
Putative formate dehydrogenase subunit alpha	fdhA	SAOUHSC_02582	gi\|123406992	0.4	0.00046
Alcohol dehydrogenase	adhA	SAOUHSC_00608	gi\|122540071	0.3	<0.00010
Formate acetyltransferase	pflB	SAOUHSC_00187	gi\|446817404	0.1	<0.00010
Bifunctional acetaldehyde-CoA/alcohol dehydrogenase	adhE	SAOUHSC_00113	gi\|88193926	0.1	<0.00010
Leukocidin-like protein 2	lukH	SAOUHSC_02243	gi\|122539025	0.1	<0.00010
Leukocidin-like protein 1	lukG	SAOUHSC_02241	gi\|122539026	0.06	0.00014
Anaerobic ribonucleoside triphosphate reductase	nrdD	SAOUHSC_02942	gi\|88196568	0.04	<0.00010
Phenol-soluble modulin alpha 1 peptide	psmA1	SAOUHSC_00411.4	gi\|206557863	0.04	<0.00010
Assimilatory nitrite reductase [NAD(P)H] large subunit	nasD	SAOUHSC_02684	gi\|88196324	0.03	<0.00010
Beta-class phenol-soluble modulin	psmB2	SAOUHSC_01135	gi\|446320817	0.03	<0.00010
Hypothetical protein	—	SAOUHSC_00144	gi\|88193956	OFF	<0.00010
Mevalonate kinase	mvaK1	SAOUHSC_00577	gi\|446119179	OFF	0.00097
Phenol-soluble modulin alpha 2 peptide	psmA2	SAOUHSC_00411.3	gi\|206557875	OFF	<0.00010

Table 2. All proteins whose abundances were significantly changed after growth for 6 h in TSB medium in the presence of 2.5 mM CuSO4, relative to control cells in TSB alone, as determined by LC-MS/MS. Column ‘P’ shows statistical significance using the Fisher's exact test.

Table 2. All proteins whose abundances were significantly changed after growth for 6 h in TSB medium in the presence of 2.5 mM CuSO₄, relative to control cells in TSB alone, as determined by LC-MS/MS. Column ‘P’ shows statistical significance using the Fisher's exact test.